Characterizing reward system neural trajectories from adolescence to young adulthood.
Characterizing reward system neural trajectories from adolescence to young adulthood.
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DOI：
10.1016/j.dcn.2021.101042
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发表时间：
2021-12
影响因子：
4.7
通讯作者：
IMAGEN consortiu
中科院分区：
文献类型：
--
作者：
Cao Z;Ottino-Gonzalez J;Cupertino RB;Juliano A;Chaarani B;Banaschewski T;Bokde ALW;Quinlan EB;Desrivières S;Flor H;Grigis A;Gowland P;Heinz A;Brühl R;Martinot JL;Martinot MP;Artiges E;Nees F;Orfanos DP;Paus T;Poustka L;Hohmann S;Millenet S;Fröhner JH;Robinson L;Smolka MN;Walter H;Winterer J;Schumann G;Whelan R;Mackey S;Garavan H;IMAGEN consortiu
在比较青少年和成年人大脑对奖励的反应的研究中，发现了不同的结果。在这里，我们研究了大样本纵向设计的奖励加工过程中的大脑反应，功能连接和任务调制的网络特性的轨迹。IMAGEN研究的参与者在时间点1（T1; n = 1304，平均年龄=14.44岁）和时间点2（T2; n = 1241，平均年龄=19.09岁）的fMRI期间执行货币奖励延迟任务。酒精使用障碍识别测试（AUDIT）在T1和T2进行，以评估参与者在过去一年中的酒精使用情况。体素线性混合效应模型被用来比较全脑反应以及腹侧纹状体（VS）的功能连接在奖励预期（大奖励与无奖励线索）之间的T1和T2。此外，任务调制网络构建了广义心理生理互动分析和总结与图论度量。为了探索酒精使用与发育的关系，参与者在T1时不使用/少量使用酒精，但在T2时将酒精使用增加到危险使用水平（即，在T1时AUDIT≤2和在T2时AUDIT ≥8的参与者）与具有持续低评分的参与者（即，T1时AUDIT≤2和T2时AUDIT ≤7的受试者）。在整个样本中，与T1相比，T2时双侧尾状核、VS、丘脑、中脑、背侧前扣带回以及左侧中央前回和中央后回的奖赏预期反应较低。相反，在T2（与T1相比）时，在双侧额下回和额中回以及右侧中央前回和中央后回观察到更大的反应。在T2时，在额叶、颞叶、顶叶和枕叶区域发现与VS的功能连接增加。任务调制网络的图论指标在T2时显示出更高的区域间连通性和拓扑效率。时间（T1 vs. T2）和酒精使用组（低vs.高）对左侧颞中回和右侧VS之间的功能连接以及任务调制网络的特征最短路径长度的交互作用。总的来说，这些结果证明了MID任务作为开发过程中典型大脑反应和网络特性的探针的实用性，以及与青少年饮酒相关的这些特征的差异，这是一种与未来负面健康结果风险增加相关的奖励相关行为。比较了T1（14岁）和T2（19岁）奖励预期期间的成像数据。在T2时，皮层下区域的脑反应降低，皮层区域的脑反应增加。功能连接（FC）与腹侧纹状体增加在T2。任务调制网络的拓扑效率在T2时增加。在T2增加饮酒最多的人中，发展模式发生了变化。
Mixed findings exist in studies comparing brain responses to reward in adolescents and adults. Here we examined the trajectories of brain response, functional connectivity and task-modulated network properties during reward processing with a large-sample longitudinal design. Participants from the IMAGEN study performed a Monetary Incentive Delay task during fMRI at timepoint 1 (T1; n = 1304, mean age=14.44 years old) and timepoint 2 (T2; n = 1241, mean age=19.09 years). The Alcohol Use Disorders Identification Test (AUDIT) was administrated at both T1 and T2 to assess a participant’s alcohol use during the past year. Voxel-wise linear mixed effect models were used to compare whole brain response as well as functional connectivity of the ventral striatum (VS) during reward anticipation (large reward vs no-reward cue) between T1 and T2. In addition, task-modulated networks were constructed using generalized psychophysiological interaction analysis and summarized with graph theory metrics. To explore alcohol use in relation to development, participants with no/low alcohol use at T1 but increased alcohol use to hazardous use level at T2 (i.e., participants with AUDIT≤2 at T1 and ≥8 at T2) were compared against those with consistently low scores (i.e., participants with AUDIT≤2 at T1 and ≤7 at T2). Across the whole sample, lower brain response during reward anticipation was observed at T2 compared with T1 in bilateral caudate nucleus, VS, thalamus, midbrain, dorsal anterior cingulate as well as left precentral and postcentral gyrus. Conversely, greater response was observed bilaterally in the inferior and middle frontal gyrus and right precentral and postcentral gyrus at T2 (vs. T1). Increased functional connectivity with VS was found in frontal, temporal, parietal and occipital regions at T2. Graph theory metrics of the task-modulated network showed higher inter-regional connectivity and topological efficiency at T2. Interactive effects between time (T1 vs. T2) and alcohol use group (low vs. high) on the functional connectivity were observed between left middle temporal gyrus and right VS and the characteristic shortest path length of the task-modulated networks. Collectively, these results demonstrate the utility of the MID task as a probe of typical brain response and network properties during development and of differences in these features related to adolescent drinking, a reward-related behaviour associated with heightened risk for future negative health outcomes. Imaging data during reward anticipation at T1 (age 14) and T2 (age 19) was compared. Brain response decreased in subcortical areas and increased in cortical areas at T2. Functional connectivity (FC) with the ventral striatum increased at T2. Topological efficiency of task-modulated network increased at T2. The developmental pattern was altered in those who increased drinking most at T2.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
影响因子：
19.9
作者：
Finn ES
通讯作者：
Finn ES
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
5.3
作者：
Boehler, Carsten N.;Hopf, Jens-Max;Noesselt, Toemme
通讯作者：
Noesselt, Toemme
静止状态功能性MRI：非塞特人一直想知道的一切。
DOI：
10.3174/ajnr.a5527
发表时间：
2018-08
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Lv H;Wang Z;Tong E;Williams LM;Zaharchuk G;Zeineh M;Goldstein-Piekarski AN;Ball TM;Liao C;Wintermark M
通讯作者：
Wintermark M