beta-Nerve growth factor (beta NGF) receptors on glial cells. Cell-cell interaction between neurones and Schwann cells in cultures of chick sensory ganglia.
beta-Nerve growth factor (beta NGF) receptors on glial cells. Cell-cell interaction between neurones and Schwann cells in cultures of chick sensory ganglia.
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神经胶质细胞上的 β 神经生长因子 (β NGF) 受体。
DOI：
10.1002/j.1460-2075.1983.tb01517.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Sutter,A
中科院分区：
文献类型：
--
作者：
Zimmermann,A;Sutter,A
迄今为止，β神经生长因子（β NGF）受体被认为是某些外周神经元的特异性细胞表面标志物，发现其在培养的鸡胚背根神经节（drg）非神经元细胞上表达（Kd β NGF = 2 × 10（-9）M）。放射自显影显示，[125 I] β NGF的结合仅限于非神经元DRG细胞亚群。培养的胚胎皮肤成纤维细胞、肝细胞、肠细胞、肌肉成纤维细胞、成肌细胞和肌管，以及巨噬细胞和细胞系3T3、3T3SV 40、BHK、BHK Py、PCC 3和ND 1不表达β NGF受体。通过设计用于制备纯许旺细胞的程序获得的非神经元drg细胞以及RN6许旺细胞瘤细胞为β NGF受体阳性。β NGF受体阳性的非神经元DRG细胞在与单个细胞以及外植体培养物中的DRG神经元相互作用中表现出典型的施万细胞行为。神经元-许旺细胞相互作用的三个阶段是可辨别的：（1）联合-神经突优先生长于β NGF受体阳性的非神经元细胞;（2）细胞分裂/增殖-β NGF受体阳性的非神经元细胞被诱导增殖并沿神经突排列和伸长;（3）鞘化-β NGF受体阳性的非神经元细胞和神经突合并的轮廓。在从胚胎阶段E6-E10制备的drg细胞培养物中，25 - 40%的非神经元细胞为β NGF受体阳性。在发育后期，从E12开始，小于或等于1%的培养的非神经元细胞表达β NGF受体。
Receptors for beta‐nerve growth factor (beta NGF), so far regarded as specific cell surface markers of certain peripheral neurones, were found to be expressed on cultured non‐neuronal cells of chick embryo dorsal root ganglia (drg) (Kd beta NGF = 2 X 10(‐9) M). Autoradiography revealed that binding of [125I] beta NGF was restricted to a subpopulation of the non‐neuronal drg cells. Cultured embryonic skin fibroblasts, liver cells, gut cells, muscle fibroblasts, myoblasts, and myotubes, as well as macrophages and the cell lines 3T3, 3T3SV40, BHK, BHK Py, PCC3 and ND1, did not express receptors for beta NGF. Non‐neuronal drg cells obtained by a procedure designed for the preparation of pure Schwann cells, as well as RN6 Schwannoma cells, were beta NGF receptor positive. The beta NGF receptor‐positive non‐neuronal drg cells displayed behaviour typical of Schwann cells in their interaction with drg neurones in single cell, as well as explant cultures. Three stages of neurone‐Schwann cell interaction were discernible: (1) association–neurites preferentially grew over beta NGF receptor‐positive non‐neuronal cells; (2) cell division/alignment–beta NGF receptor‐positive non‐neuronal cells were induced to proliferate and aligned and elongated along neurites; (3) ensheathment–the outline of beta NGF receptor‐positive non‐neuronal cells and neurites merged. In drg cell cultures prepared from embryonic stages E6‐E10, 25‐40% of the non‐neuronal cells were beta NGF receptor‐positive. Later in development, from E12 onward, less than or equal to 1% of the cultured non‐neuronal cells expressed beta NGF receptors.
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DOI：
--
发表时间：
1973
期刊：
Archives of Environmental Health An International Journal
影响因子：
--
作者：
Peter J. Nord;Murali P. Kadaba;John R. J. Sorenson
通讯作者：
John R. J. Sorenson
DOI：
10.1002/tera.1420200107
发表时间：
1979-01-01
期刊：
TERATOLOGY
影响因子：
--
作者：
CHEN, WJ;BODY, RL;MOTTET, NK
通讯作者：
MOTTET, NK
影响人类头皮头发中汞含量的因素。
影响因子：
12.7
作者：
S. Yamaguchi;H. Matsumoto;S. Kaku;M. Tateishi;M. Shiramizu
通讯作者：
M. Shiramizu
影响因子：
10.4
作者：
Galster WA
通讯作者：
Galster WA
影响因子：
8.3
作者：
EADS, EA;LAMBDIN, CE
通讯作者：
LAMBDIN, CE