Contribution of Adipose Tissue to Development of Cancer.
Contribution of Adipose Tissue to Development of Cancer.
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DOI：
10.1002/cphy.c170008
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发表时间：
2017-12-12
影响因子：
5.8
通讯作者：
Makowski L
中科院分区：
文献类型：
--
作者：
Cozzo AJ;Fuller AM;Makowski L
实体瘤的生长和转移需要肿瘤细胞与周围组织的相互作用，导致肿瘤被视为组织水平的现象，而不仅仅是细胞内在的异常。由于脂肪组织的普遍性，许多类型的实体瘤生长在与脂肪细胞和脂肪相关的基质和血管成分接近或直接接触的地方，如成纤维细胞和其他结缔组织细胞、干细胞和祖细胞、内皮细胞、先天和适应性免疫细胞、细胞外信号和基质成分。肥胖中的过度脂肪增加了癌症发展的风险，并对几种癌症类型的预后产生负面影响，部分原因是与脂肪组织细胞群相互作用。在此，我们回顾了脂肪“器官”的细胞和非细胞成分，并讨论了这些不同的微环境成分促进肿瘤发展的机制，特别强调肥胖。由于乳腺癌和前列腺癌在美国的患病率，它们在解剖学上与脂肪组织库的密切接近，以及它们与肥胖的复杂流行病学关联，我们特别强调脂肪组织对这些癌症类型的发生和发展的贡献的研究。肥胖以多种方式显著改变脂肪组织微环境，包括诱导纤维化和血管生成，增加干细胞丰度，以及促炎免疫细胞的扩增。由于许多这些变化也类似于在肿瘤微环境中观察到的变化，靠近脂肪组织可能为肿瘤的发展提供了一个有利的环境，提供了肥胖和肿瘤发生之间的关键联系。
Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tissue, many types of solid tumors grow in proximate or direct contact with adipocytes and adipose-associated stromal and vascular components, such as fibroblasts and other connective tissue cells, stem and progenitor cells, endothelial cells, innate and adaptive immune cells, and extracellular signaling and matrix components. Excess adiposity in obesity both increases risk of cancer development and negatively influences prognosis in several cancer types, in part due to interaction with adipose tissue cell populations. Herein, we review the cellular and noncellular constituents of the adipose “organ,” and discuss the mechanisms by which these varied microenvironmental components contribute to tumor development, with special emphasis on obesity. Due to the prevalence of breast and prostate cancers in the United States, their close anatomical proximity to adipose tissue depots, and their complex epidemiologic associations with obesity, we particularly highlight research addressing the contribution of adipose tissue to the initiation and progression of these cancer types. Obesity dramatically modifies the adipose tissue microenvironment in numerous ways, including induction of fibrosis and angiogenesis, increased stem cell abundance, and expansion of proinflammatory immune cells. As many of these changes also resemble shifts observed within the tumor microenvironment, proximity to adipose tissue may present a hospitable environment to developing tumors, providing a critical link between adiposity and tumorigenesis.
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巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
影响因子：
17.1
作者：
Amarnath S;Mangus CW;Wang JC;Wei F;He A;Kapoor V;Foley JE;Massey PR;Felizardo TC;Riley JL;Levine BL;June CH;Medin JA;Fowler DH
通讯作者：
Fowler DH
影响因子：
3.8
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
通讯作者：
Coates, Ralph J.
影响因子：
11.2
作者：
Arendt LM;McCready J;Keller PJ;Baker DD;Naber SP;Seewaldt V;Kuperwasser C
通讯作者：
Kuperwasser C
影响因子：
3.6
作者：
Atherton, AJ;Warburton, MJ;Gusterson, BA
通讯作者：
Gusterson, BA