Thermosensory Transient Receptor Potential Ion Channels and Asthma.
Thermosensory Transient Receptor Potential Ion Channels and Asthma.
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DOI：
10.3390/biomedicines9070816
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发表时间：
2021-07-14
期刊：
影响因子：
4.7
通讯作者：
Perelman JM
中科院分区：
文献类型：
--
作者：
Kytikova OY;Novgorodtseva TP;Denisenko YK;Naumov DE;Gvozdenko TA;Perelman JM
哮喘是一种广泛存在的支气管肺系统慢性疾病，由于其复杂的发病机制，其病程具有异质性。自然气候和人为因素在这种病理的发生和进展中发挥着重要作用。物理和化学环境刺激的接收以及体温的调节是由热感觉通道介导的，热感觉通道是瞬时受体电位（TRP）离子通道亚家族的成员。已经发现编码香草素、锚蛋白和褪黑素TRP通道的基因参与一些哮喘表型的发展以及这种病理学恶化的形成。该综述总结了关于高温和低温在哮喘气道炎症中的作用的现代观点。描述了热感 TRP 通道（香草酸、锚蛋白和褪黑素 TRP 通道）参与对高温、低温和空气湿度的反应以及支气管高反应性和哮喘伴随的呼吸道症状的形成。讨论了热敏 TRP 通道功能的遗传方面。表明治疗由温度和湿度影响引起的哮喘加重的新方法应基于通道活性的调节。
Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity.
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