Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations.
Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations.
复制标题
偏头痛的反应抑制改变：来自事件相关电位和诱发振荡的证据
DOI：
10.1186/s10194-020-01187-2
复制
发表时间：
2020-10-02
期刊：
影响因子：
--
通讯作者：
Yu S
中科院分区：
文献类型：
--
作者：
Chen G;Li Y;Dong Z;Wang R;Zhao D;Obeso I;Yu S
背景偏头痛是一种对环境刺激的超敏反应，在头痛发作时达到高潮，但在无发作期仍持续存在。尽管正在进行的争论的性质的机制引起这种异常，存在缺陷的抑制性皮层过程已被提出是一个可能的机制，其发病机制。支持这一主张的经验证据主要是基于先前的帐户显示功能性皮质不兴奋的感觉域。考虑到一般抑制控制过程可以在信息处理的早期到后期发挥重要作用，这可能表明抑制控制的其他维度在偏头痛残疾中发挥重要作用。本研究探讨的病理生理学特征的抑制控制，发生在prepotent responses在migraineurs.Methods22例无先兆偏头痛患者（平均年龄= 30.86 ± 5.69岁; 19名女性）在发作间期和25名健康对照（平均年龄= 30.24 ± 3.52岁; 18名女性）被招募。我们使用了一个停止信号任务结合事件相关电位（ERPs）来检查参与者的神经活动支持响应inhibit.ResultsBehaviorally，偏头痛患者表现出延长停止信号反应时间相对于健康对照组。在神经水平上，额中央，中央和中央-顶叶头皮区域，ERP的一个组成部分，在早期，非运动阶段的抑制，冲突监测相关的停止-N2的振幅显着增加偏头痛。与此同时，在中央和中央顶叶头皮区域的停止P3的振幅，反映运动系统的晚期抑制和运动抑制的认知评价的ERP的一个组成部分，也显着增加偏头痛。最终，我们的时间-频率分析进一步揭示了偏头痛患者的三角洲活动增加。结论与认知皮层过程的改变是偏头痛的关键特征的理论相一致，我们的研究结果揭示了抑制偏头痛患者的优势反应的异常状态，这可以归因于前额叶执行网络和中央-顶叶感觉运动网络的皮层非兴奋性。这些新的发现延伸到显示存在功能障碍的抑制控制，发生在抑制migraneurs的优势反应。
BackgroundMigraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs.MethodsTwenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition.ResultsBehaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs.ConclusionsConsistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.
登录
查看更多内容
影响因子：
3
作者：
Chen G;Zhang L;Ding W;Zhou R;Xu P;Lu S;Sun L;Jiang Z;Li H;Li Y;Cui H
通讯作者：
Cui H
影响因子：
56.9
作者：
Bonini, Francesca;Burle, Boris;Vidal, Franck
通讯作者：
Vidal, Franck
影响因子：
9.9
作者：
Aurora, SK;Ahmad, BK;Ramadan, NM
通讯作者：
Ramadan, NM
DOI：
10.1186/s10194-016-0712-z
发表时间：
2017-12
期刊：
The journal of headache and pain
影响因子：
--
作者：
Cortese F;Coppola G;Di Lenola D;Serrao M;Di Lorenzo C;Parisi V;Pierelli F
通讯作者：
Pierelli F
影响因子：
5
作者：
Burch, Rebecca C.;Loder, Stephen;Smitherman, Todd A.
通讯作者：
Smitherman, Todd A.