Can brain state be manipulated to emphasize individual differences in functional connectivity?
Can brain state be manipulated to emphasize individual differences in functional connectivity?
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DOI：
10.1016/j.neuroimage.2017.03.064
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发表时间：
2017-10-15
期刊：
影响因子：
5.7
通讯作者：
Constable RT
中科院分区：
文献类型：
--
作者：
Finn ES;Scheinost D;Finn DM;Shen X;Papademetris X;Constable RT
虽然神经影像学研究通常会破坏来自许多受试者的数据，但大脑功能组织在个体之间存在差异，而表征这种差异对于将大脑活动与行为表型联系起来至关重要。休息已成为探索个体差异的默认状态，主要是因为它很容易获得，而且是一个假定的中性背景。然而，休息是个体差异研究的最佳条件的假设在很大程度上未经检验。事实上，其他大脑状态可能提供更好的受试者内部与受试者之间变异性比率，从而促进生物标志物的发现。根据所研究的特征或行为，某些任务可能会在受试者之间产生有意义的特质，从本质上增强感兴趣网络中的个体信号，超出了在休息时可以测量的范围。在这里，我们回顾了关于大脑状态如何影响功能连接个体差异的理论考虑和现有工作，使用人类连接组项目的数据对不同条件下的受试者内部和受试者之间的变异性进行了一些初步分析，并概述了未来研究的问题。
While neuroimaging studies typically collapse data from many subjects, brain functional organization varies between individuals, and characterizing this variability is crucial for relating brain activity to behavioral phenotypes. Rest has become the default state for probing individual differences, chiefly because it is easy to acquire and a supposed neutral backdrop. However, the assumption that rest is the optimal condition for individual differences research is largely untested. In fact, other brain states may afford a better ratio of within- to between-subject variability, facilitating biomarker discovery. Depending on the trait or behavior under study, certain tasks may bring out meaningful idiosyncrasies across subjects, essentially enhancing the individual signal in networks of interest beyond what can be measured at rest. Here, we review theoretical considerations and existing work on how brain state influences individual differences in functional connectivity, present some preliminary analyses of within- and between-subject variability across conditions using data from the Human Connectome Project, and outline questions for future study.
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影响因子：
3.7
作者：
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通讯作者：
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DOI：
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DOI：
10.1073/pnas.0900234106
发表时间：
2009-05-26
影响因子：
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影响因子：
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