Leukoaraiosis severity and list-learning in dementia.

Leukoaraiosis severity and list-learning in dementia.
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DOI:
10.1080/13854040802681664
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发表时间:
2009-08
期刊:
The Clinical neuropsychologist
影响因子:
--
通讯作者:
Libon DJ
Libon DJ
中科院分区:
其他
文献类型:
--
作者:
Price CC;Garrett KD;Jefferson AL;Cosentino S;Tanner JJ;Penney DL;Swenson R;Giovannetti T;Bettcher BM;Libon DJ

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在痴呆患者中,脑白质疏松症(LA)被假设为导致言语系列列表学习测试的不同模式的损害。使用视觉评定量表,将144名缺血评分<4的痴呆患者重新分类为轻度(n = 73)、中度(n = 44)或重度LA(n = 27)。轻度LA被预测与遗忘列表学习特征相关,而重度LA被预测与执行障碍特征相关。列表学习性能标准化一组健康的老年人(n = 24)。对来自列表学习范式的四个因素以及错误评分进行了分析。数据表明,LA严重程度是理解痴呆症列表学习的重要标志。
In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
DOI: 10.1001/archneur.1987.00520130013009
发表时间: 1987-01-01
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