Association of vitamin D status and blood pressure response after renal denervation
Association of vitamin D status and blood pressure response after renal denervation
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去肾神经术后维生素 D 状态与血压反应的关系
DOI：
10.1007/s00392-013-0621-y
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发表时间：
2013
影响因子：
5
通讯作者：
M. Böhm
中科院分区：
文献类型：
--
作者：
J. Pöss;F. Mahfoud;C. Ukena;M. Esler;M. Schlaich;D. Hering;B. Cremers;U. Laufs;M. Böhm
背景维生素D缺乏与高血压有关；然而，维生素D是否影响治疗降压尚不清楚。去肾交感神经(RDN)可降低顽固性高血压患者的血压。我们推测维生素D可能影响RDN对血压的反应。分析维生素D水平与术后6个月收缩压下降的关系。结果基线时办公室平均收缩压为171.5±0.2毫米汞柱。治疗后，平均办公室收缩压下降28.4%±22.3%(p=0.007)。85例(84.2%)SBP下降&10毫米汞柱(应答者)。无应答者维生素D浓度低于应答者(9.9%±44.5vs.13.7%±67.4%ng/ml，p=0.008)。与应答者相比，无应答者(n=16，15.8%)的维生素D浓度更多地低于中位数(81对46%，p=0.013)。维生素D浓度正常的患者的百分比随着收缩压下降幅度的增加而增加(趋势P=0.0.020)。维生素D浓度低于中位数的患者的收缩压下降幅度低于维生素D浓度高于中位数的患者(23.5%±33.2vs.33.7%±33.2%，p=0.026)。基础维生素D水平与收缩压下降呈正相关(r=0.202，p=0.043)。结论在顽固性高血压患者中，低水平的维生素D水平与收缩压反应降低和无反应率高相关。
BackgroundVitamin D deficiency is associated with hypertension; however, it is unclear whether vitamin D influences therapeutic blood pressure reduction. Renal sympathetic denervation (RDN) reduces blood pressure in resistant hypertension. We hypothesized that vitamin D might influence blood pressure response to RDN.MethodsVitamin D was measured in 101 patients with resistant hypertension undergoing RDN. The associations between vitamin D status and systolic blood pressure (SBP) reduction 6 months after RDN were analyzed.ResultsMean office SBP at baseline was 171.5 ± 2 mmHg. After RDN, mean office SBP was reduced by 28.4 ± 2.3 mmHg (p = 0.007). 85 patients (84.2 %) had SBP reductions >10 mmHg (responders). Vitamin D concentrations were lower in non-responders as compared to responders (9.9 ± 4.5 vs. 13.7 ± 7.4 ng/ml, p = 0.008). Non-responders (n = 16, 15.8 %), more often had a vitamin D concentration below the median as compared to responders (81 vs. 46 %, p = 0.013). The percentage of patients with normal vitamin D concentrations increased with increasing tertiles of SBP reduction (p for trend = 0.020). In patients with vitamin D concentrations below the median, SBP reduction was lower as compared to patients with a vitamin D concentration above the median (23.5 ± 3.2 vs. 33.7 ± 3.2 mmHg, p = 0.026). Baseline vitamin D concentrations correlated with SBP reduction (r = 0.202, p = 0.043).ConclusionsIn patients with resistant hypertension, low vitamin D concentrations were associated with a decreased SBP response and a higher rate of non-response.
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影响因子：
--
作者：
Martins, David;Wolf, Myles;Norris, Keith
通讯作者：
Norris, Keith
影响因子：
120.7
作者：
Thadhani, Ravi;Appelbaum, Evan;Solomon, Scott D.
通讯作者：
Solomon, Scott D.
女性维生素 D 和钙的摄入量与血压的关系。
DOI：
10.1093/ajcn/42.1.135
发表时间：
1985
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Sowers,MR;Wallace,RB;Lemke,JH
通讯作者：
Lemke,JH
影响因子：
39.2
作者：
RESNICK, LM;MULLER, FB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
5.8
作者：
Johns, Edward J.;Kopp, Ulla C.;DiBona, Gerald F.
通讯作者：
DiBona, Gerald F.