Advancing our understanding of the neural control of the female human urethra.
Advancing our understanding of the neural control of the female human urethra.
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促进我们对女性人类尿道神经控制的理解。
DOI：
10.1002/nau.24807
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发表时间：
2022-01
影响因子：
2
通讯作者：
Keast JR
中科院分区：
文献类型：
--
作者：
Yang CC;Hokanson JA;Keast JR
目前与尿道相关的下尿路功能障碍（LUTD）的治疗集中在其解剖位置（作为悬吊和骨盆内其他悬吊方法的目标）、其与骨盆底的综合作用（作为物理治疗的目标）以及其组织完整性（作为激素替代和药物治疗的目标）。但尿道不是一个被动的管道，尿液通过膀胱：它是一个动态的结构，与膀胱合作，以实现尿液的储存和释放。尿道及其括约肌的功能是在膀胱充盈期间保持通畅，并在排尿期间适当地允许尿液畅通。这些功能由大脑、脊髓、神经节和神经的神经回路调节。改善LUTD靶向尿道的治疗将需要增加对调节尿道和膀胱的回路的神经解剖学和神经生理学的知识，并将这些知识与肌肉生物力学和流体动力学的表征相结合。为了评估关于尿道的现有知识并刺激新的方法来填补知识空白，国家糖尿病、消化和肾脏疾病研究所（NIDDK）赞助了一个题为“女性尿道功能和衰竭：推进生殖泌尿系统疾病的基础和转化研究”（2020年10月）。讨论的一个领域是尿道的神经控制--既有已知的，又有哪些领域需要更多的扩展，以促进我们对该领域的理解。在此基础上，作为会议小组努力的结果，我们提出了几种方法，这些方法有可能填补我们对尿道功能和功能障碍的神经贡献者的理解中的主要知识空白。我们的目标不是提供
Current treatment of lower urinary tract dysfunction (LUTD) related to the urethra focuses on its anatomic position (as the target for slings and other methods of suspension within the pelvis), its integrated role with the pelvic floor (as the target of physical therapy), and its tissue integrity (as the target for hormonal replacement and medications). But the urethra is not a passive conduit for urine to pass out of the bladder: it is a dynamic structure working in concert with the bladder to achieve urine storage and release. The function of the urethra and its sphincters is to maintain continence during bladder filling and appropriately allow unobstructed passage of urine during voiding. These functions are regulated by neural circuits of the brain, spinal cord, ganglia and nerves. Improving therapy for LUTD targeting the urethra will require growth of knowledge of the neuroanatomy and neurophysiology of circuits regulating the urethra and bladder, and integration of this knowledge with characterization of muscle biomechanics and fluid dynamics.To evaluate existing knowledge on the urethra and stimulate new approaches to fill knowledge gaps, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored a virtual seminar series entitled “Female Urethral Function and Failure: Advancing Basic and Translational Research for Genitourinary Conditions”(October 2020). One area of discussion was the neural control of the urethra--both what is known, and what areas need more expansion, in order to advance our understanding of the field. Building on this initiative and as a result of the group effort of the meeting, here we propose several approaches that have the potential to fill major knowledge gaps in our understanding of neural contributors to urethra function and dysfunction. Our goal here is not to provide
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影响因子：
14.5
作者：
North, Robert Y.;Li, Yan;Dougherty, Patrick M.
通讯作者：
Dougherty, Patrick M.
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2
作者：
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通讯作者：
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