IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.
IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.
复制标题
IL-13可能在中国汉族人群的不同条件下通过不同机制参与CAD的发生
DOI：
10.1038/s41598-018-24592-9
复制
发表时间：
2018-04-18
影响因子：
4.6
通讯作者：
Cheng X
中科院分区：
文献类型：
--
作者：
Zha LF;Nie SF;Chen QW;Liao YH;Zhang HS;Dong JT;Xie T;Wang F;Tang TT;Xia N;Xu CQ;Zhou YC;Zeng ZP;Jiao J;Wang PY;Wang QK;Tu X;Cheng X
白细胞介素-13（IL-13）在动脉粥样硬化中具有重要作用，但其在冠状动脉疾病（CAD）中的作用尚不清楚。在这里，我们使用覆盖整个IL-13基因的标签SNP（即，rs 1881457、rs 2069744和rs 20541）和包含1863例CAD病例和1841例对照的两阶段队列。冠心病的传统危险因素，如年龄，BMI和其他因素，被用作logistic回归分析的协变量。在总人群中，我们发现IL 13的两种单倍型（ATG和ATA，顺序为rs 1881457 C-rs 2069744 T-rs 20541 A）显著增加了CAD的风险，调整后的p值小于0.05（分别为padj= 0.019和padj = 0.042）。在亚组人群分析中，发现变异rs 1881457 C显著导致男性CAD风险增加近2倍（padj= 0.023，OR = 1.91，95%CI：1.09-3.33）。rs 1881457 C变异也显著增加了近2倍的迟发性CAD风险（padj= 0.024，OR = 1.93，95%CI：1.09-3.42）。结论：IL 13可能通过不同的机制参与了中国汉族人群不同条件下的冠心病发病。
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the wholeIL13gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes ofIL13(ATG and ATA, ordered rs1881457C-rs2069744T-rs20541A) significantly contributed to the risk of CAD with adjustedpvalues less than 0.05 (padj= 0.019 andpadj= 0.042, respectively). In subgroup population analyses, the variant rs1881457Cwas found to significantly contribute to a nearly two fold increase in the risk of CAD in men (padj= 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457Calso significantly contributed to a nearly twofold risk of late-onset CAD (padj= 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion,IL13might be involved in CAD via different mechanisms under different conditions in the Chinese Han population.
登录
查看更多内容
中国汉族人群IL27变异与冠心病的遗传关联分析
影响因子：
4.6
作者：
Fan Q;Nie S;Li S;Liao Y;Zhang H;Zha L;Wang F;Tang T;Xia N;Xu C;Wang P;Xie T;Xie J;Lu Q;Li Q;Qian J;Li B;Wu G;Wu Y;Yang Y;Wang QK;Tu X;Cheng X
通讯作者：
Cheng X
影响因子：
5.4
作者：
Amit U;Kain D;Wagner A;Sahu A;Nevo-Caspi Y;Gonen N;Molotski N;Konfino T;Landa N;Naftali-Shani N;Blum G;Merquiol E;Karo-Atar D;Kanfi Y;Paret G;Munitz A;Cohen HY;Ruppin E;Hannenhalli S;Leor J
通讯作者：
Leor J
影响因子：
30.8
作者：
Howson JMM;Zhao W;Barnes DR;Ho WK;Young R;Paul DS;Waite LL;Freitag DF;Fauman EB;Salfati EL;Sun BB;Eicher JD;Johnson AD;Sheu WHH;Nielsen SF;Lin WY;Surendran P;Malarstig A;Wilk JB;Tybjærg-Hansen A;Rasmussen KL;Kamstrup PR;Deloukas P;Erdmann J;Kathiresan S;Samani NJ;Schunkert H;Watkins H;CARDIoGRAMplusC4D;Do R;Rader DJ;Johnson JA;Hazen SL;Quyyumi AA;Spertus JA;Pepine CJ;Franceschini N;Justice A;Reiner AP;Buyske S;Hindorff LA;Carty CL;North KE;Kooperberg C;Boerwinkle E;Young K;Graff M;Peters U;Absher D;Hsiung CA;Lee WJ;Taylor KD;Chen YH;Lee IT;Guo X;Chung RH;Hung YJ;Rotter JI;Juang JJ;Quertermous T;Wang TD;Rasheed A;Frossard P;Alam DS;Majumder AAS;Di Angelantonio E;Chowdhury R;EPIC-CVD;Chen YI;Nordestgaard BG;Assimes TL;Danesh J;Butterworth AS;Saleheen D
通讯作者：
Saleheen D
影响因子：
30.8
作者：
Nelson, Christopher P.;Goel, Anuj;Deloukas, Panos
通讯作者：
Deloukas, Panos
影响因子：
3.8
作者：
Bao, Katherine;Reinhardt, R. Lee
通讯作者：
Reinhardt, R. Lee