Morphological and physiological development of auditory synapses.

Morphological and physiological development of auditory synapses.
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DOI:
10.1016/j.heares.2014.01.007
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发表时间:
2014-05
期刊:
影响因子:
2.8
通讯作者:
Goodrich, Lisa V.
Goodrich, Lisa V.
中科院分区:
医学1区
文献类型:
--
作者:
Yu, Wei-Ming;Goodrich, Lisa V.

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声音交流需要收集、转换和解释不同的声音线索。为了实现这一目标,必须在初级感觉神经元的放电模式中捕获复杂声音刺激的所有空间和时间特征,然后沿着听觉通路准确地传输以进行额外的处理。哺乳动物的听觉系统依靠几个具有独特性质的突触来完成这项任务:听觉带突触、Held 尾球和 Held 花萼。这些突触中的每一个都发展出形态学和电生理学特征,这些特征能够实现非常精确的信号传输,以传达声音定位背后的微小时序差异。在本文中,我们回顾了有关这些突触如何发育和成熟以获得听觉所需的专门特征的当前知识。
Acoustic communication requires gathering, transforming, and interpreting diverse sound cues. To achieve this, all the spatial and temporal features of complex sound stimuli must be captured in the firing patterns of the primary sensory neurons and then accurately transmitted along auditory pathways for additional processing. The mammalian auditory system relies on several synapses with unique properties in order to meet this task: the auditory ribbon synapses, the endbulb of Held, and the calyx of Held. Each of these synapses develops morphological and electrophysiological characteristics that enable the remarkably precise signal transmission necessary for conveying the miniscule differences in timing that underly sound localization. In this article, we review the current knowledge of how these synapses develop and mature to acquire the specialized features necessary for the sense of hearing.
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