The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza.
The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza.
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丹参中丹参酮和酚酸的生物合成途径
DOI：
10.3390/molecules200916235
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发表时间：
2015-09-08
期刊：
影响因子：
--
通讯作者：
Huang LQ
中科院分区：
文献类型：
--
作者：
Ma XH;Ma Y;Tang JF;He YL;Liu YC;Ma XJ;Shen Y;Cui GH;Lin HX;Rong QX;Guo J;Huang LQ
植物次生代谢产物在人类医药和化学工业中起着重要作用。由于植物体内次生代谢产物的积累有限，而次生代谢产物又具有重要的作用，因此研究植物次生代谢途径中的关键酶，将有助于代谢工程或合成生物学在植物或微生物中改良或生产这些化合物，为生产这些有价值的化合物提供一种新的途径。丹参含有丹参酮和酚酸类活性成分，广泛用于心脑血管疾病的治疗。对S.由于成功的遗传转化体系、简化的毛状根系统和高通量测序，丹参的研究取得了很大进展。克隆的基因在S.丹参为丹参酮和酚酸类化合物生物合成中的后修饰步骤的功能表征以及这些步骤在代谢工程中的进一步利用提供了参考。这些研究策略为进一步阐明其他植物中二萜类化合物和酚酸类化合物的生物合成途径提供了坚实的基础。本文系统地综述了丹参酮和酚酸类化合物的生物合成途径分析以及丹参次生代谢限速基因的合成生物学和代谢工程应用研究进展。丹参。
Secondary metabolites from plants play key roles in human medicine and chemical industries. Due to limited accumulation of secondary metabolites in plants and their important roles, characterization of key enzymes involved in biosynthetic pathway will enable metabolic engineering or synthetic biology to improve or produce the compounds in plants or microorganisms, which provides an alternative for production of these valuable compounds. Salvia miltiorrhiza, containing tanshinones and phenolic acids as its active compounds, has been widely used for the treatment of cardiovascular and cerebrovascular diseases. The biosynthetic analysis of secondary metabolites in S. miltiorrhiza has made great progress due to the successful genetic transformation system, simplified hairy roots system, and high-throughput sequencing. The cloned genes in S. miltiorrhiza had provided references for functional characterization of the post-modification steps involved in biosynthesis of tanshinones and phenolic acids, and further utilization of these steps in metabolic engineering. The strategies used in these studies could provide solid foundation for elucidation of biosynthetic pathways of diterpenoids and phenolic acids in other species. The present review systematically summarizes recent advances in biosynthetic pathway analysis of tanshinones and phenolic acids as well as synthetic biology and metabolic engineering applications of the rate-limiting genes involved in the secondary metabolism in S. miltiorrhiza.
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影响因子：
3.2
作者：
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