Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature.
Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature.
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DOI：
10.1186/1746-1596-7-64
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发表时间：
2012-06-08
影响因子：
2.6
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Li Y;Wang XB;Tian XY;Li B;Li Z
霍奇金淋巴瘤（HL）通常表现为淋巴结病变，在疾病进展过程中可能累及淋巴结部位。没有任何淋巴结关联的原发性骨HL是极其罕见的，文献中仅描述了少数此类病例。我们提出了一个不寻常的情况下，主要HL肋骨发生在中年女性患者。计算机断层扫描（CT）显示溶骨性病变位于右侧第二肋骨，并与大的软组织肿块相关。无局部淋巴结受累。进行颈部和腹部CT扫描，未发现病理学发现，尤其是未观察到淋巴结病和器官肿大。组织学上，典型的双核Reed-Sternberg（RS）细胞和腔隙细胞散在反应性炎症背景中，伴淋巴细胞、组织细胞和嗜酸性粒细胞浸润。免疫组化显示，RS细胞和腔隙细胞呈典型的膜样和核旁点状染色，CD 15和CD 30呈阳性。然而，这些细胞是阴性的EB病毒检测原位杂交。诊断为原发性骨性HL。患者接受全身化疗和局部放疗，并定期随访24个月。无肿瘤复发、淋巴结转移及骨髓转移。由于系统性HL有继发性骨受累的可能性，因此，当其表现为孤立性骨病变时，严格的组织学分析和彻底的影像学检查对于准确诊断该肿瘤是必要的。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/2846916171507084
Hodgkin lymphoma (HL) typically presents as nodal lesion and may involve extranodal sites during the progression of the disease. Primary osseous HL without any lymph node association is extremely rare and only a few such cases have been described in the literature. We present a case of unusual primary HL in rib occurring in a middle-aged female patient. Computed tomography (CT) scan revealed an osteolytic lesion was located at the right second rib and was associated with a large soft tissue mass. There was no regional lymph node involvement. CT scan of neck and abdomen was performed and showed no pathologic findings, particularly no lymphadenopathy and organomegaly could be observed. Histologically, typical binucleated Reed-Sternberg (RS) cells and lacunar cells were scattered in the background of reactive inflammation with infiltration of lymphocytes, histiocytes and eosinophilic granulocytes. By immunohistochemistry, RS cells and lacunar cells were positive for CD15 and CD30 with typical membrane and paranuclear dot-like staining pattern. However, these cells were negative for Epstein-Barr virus detection by in situ hybridization. A diagnosis of primary osseous HL was made. The patient received systemic chemotherapy and local radiotherapy, and was on regular follow-up for 24 months. There was no sign of recurrence of tumor and lymph node or bone marrow involvement. Because there is a possibility of secondary bone involvement by systemic HL, strict histological analysis and thorough radiographic examination are suggested to be necessary for accurately diagnosing this tumor when it presents as a solitary bone lesion. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2846916171507084
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影响因子：
2.6
作者：
Gaiser T;Geissinger E;Schattenberg T;Scharf HP;Dürken M;Dinter D;Rosenwald A;Marx A
通讯作者：
Marx A
DOI：
10.1182/asheducation-2009.1.491
发表时间：
2009-01-01
期刊：
Hematology. American Society of Hematology. Education Program
影响因子：
--
作者：
Kuppers, Ralf
通讯作者：
Kuppers, Ralf
影响因子：
0.9
作者：
Breibach, Florence;Julian, Anne;Gomez-Brouchet, Anne
通讯作者：
Gomez-Brouchet, Anne
DOI：
10.1111/j.1440-1673.1993.tb00011.x
发表时间：
1993-02-01
期刊：
Australasian radiology
影响因子：
--
作者：
Borg, M F;Chowdhury, A D;Benjamin, C S
通讯作者：
Benjamin, C S
DOI：
10.1007/s00432-004-0641-0
发表时间：
2005-03-01
影响因子：
3.6
作者：
Gebert, C;Hardes, J;Gosheger, G
通讯作者：
Gosheger, G