Subchondral bone as a novel target for regenerative therapy of osteochondritis dissecans: A case report.

Subchondral bone as a novel target for regenerative therapy of osteochondritis dissecans: A case report.
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DOI:
10.12998/wjcc.v9.i15.3623
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发表时间:
2021-05-26
影响因子:
1.1
通讯作者:
Tong PJ
Tong PJ
中科院分区:
医学4区
文献类型:
--
作者:
Zhang SY;Xu HH;Xiao MM;Zhang JJ;Mao Q;He BJ;Tong PJ

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剥脱性骨软骨炎(OCD)是一种病因不明的罕见疾病,其特征是软骨下骨损伤和覆盖软骨缺损。目前的报告提出的结果,软骨下骨作为一个新的目标植入外周血干细胞(PBSC)在治疗强迫症。一名16岁的强迫症患者接受了PBSC的软骨下骨植入。4个月后,患者的视觉模拟量表评分、西安大略和麦克马斯特大学骨关节炎指数以及全器官磁共振成像评分显著改善,磁共振成像观察到软骨和软骨下骨再生。这是第一例以软骨下骨作为PBSC植入靶点治疗强迫症的病例,这突出了软骨下骨对软骨修复的重要性。这种治疗可能是强迫症关节软骨和软骨下骨恢复的潜在选择。
Osteochondritis dissecans (OCD) is a rare disease of unclear cause characterized by subchondral bone damage and overlying cartilage defects. The current report presents the results of subchondral bone as a novel target for implantation of peripheral blood stem cells (PBSCs) in the treatment of OCD. A 16-year-old patient diagnosed with OCD underwent subchondral bone implantation of PBSCs. Four months later, the patient's visual analog scale scores, Western Ontario and McMaster University osteoarthritis index, and whole-organ magnetic resonance imaging score improved significantly, and regeneration of cartilage and subchondral bone was observed on magnetic resonance imaging. This is the first case of OCD treated with subchondral bone as an implantation target of PBSCs, which highlights the importance of subchondral bone for cartilage repair. This treatment could be a potential option for articular cartilage and subchondral bone recovery in OCD.
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