Differential induction of glucose‐regulated and heat shock proteins: Effects of pH and sulfhydryl‐reducing agents on chicken embryo cells
Differential induction of glucose‐regulated and heat shock proteins: Effects of pH and sulfhydryl‐reducing agents on chicken embryo cells
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葡萄糖调节蛋白和热休克蛋白的差异诱导：pH 和巯基还原剂对鸡胚细胞的影响
DOI：
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发表时间：
1985
影响因子：
5.6
通讯作者：
L. Hightower
中科院分区：
文献类型：
--
作者：
S. Whelan;L. Hightower
葡萄糖调节蛋白和热休克蛋白是真核生物应激蛋白的两个亚类，它们可以被差异地、同时地和交替地诱导。发现了两种新的诱导剂，即低胞外pH和2-巯基乙醇，它们能刺激鸡胚细胞快速合成葡萄糖调节蛋白，并将巯基乙醇的细胞靶点分为两类，一类依赖于蛋白质合成，另一类不依赖于蛋白质合成。此外，还发现了一种新的热休克蛋白诱导剂--高胞外pH。放线菌素D抑制低和高胞外pH值的诱导，但放线菌酮不敏感。葡萄糖调节蛋白和热休克蛋白的诱导在细胞内pH值和巯基氧化态的变化方面进行了讨论。
Glucose‐regulated and heat shock proteins are two subsets of eukaryotic stress proteins that can be induced differentially, simultaneously, and reciprocally. Two new inducers, low extracellular pH and 2‐mercaptoethanol, that stimulate chicken embryo cells to synthesize glucose‐regulated proteins rapidly were found. Two classes of cellular targets for mercaptoethanol were defined operationally, one dependent on and the other independent of protein synthesis. A new inducer of heat shock proteins, high extracellular pH, was found as well. Inductions by low and high extracellular pH were inhibited by actinomycin D but were insensitive to cycloheximide. Inductions of glucose‐regulated and heat shock proteins are discussed in terms of changes in intracellular pH and sulfhydryl oxidation states.
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DOI：
10.1073/pnas.79.10.3218
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
LI, GC;WERB, Z
通讯作者：
WERB, Z
长期缺氧的中国仓鼠成纤维细胞的热耐受性和特异性蛋白质合成。
影响因子：
3.7
作者：
Li,GC;Shrieve,DC
通讯作者：
Shrieve,DC
DOI：
10.1073/pnas.80.24.7496
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
LEE, PC;BOCHNER, BR;AMES, BN
通讯作者：
AMES, BN
DOI：
10.1073/pnas.78.8.4922
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
LEE, AS;DELEGEANE, A;SCHARFF, D
通讯作者：
SCHARFF, D
仓鼠成纤维细胞中葡萄糖饥饿诱导两个基因。
DOI：
10.1073/pnas.81.4.988
发表时间：
1984
影响因子：
11.1
作者：
Lin,AY;Lee,AS
通讯作者：
Lee,AS