Aberrant Peripheral Immune Function in a Good Syndrome Patient.
Aberrant Peripheral Immune Function in a Good Syndrome Patient.
复制标题
良好综合征患者的异常外周免疫功能
DOI：
10.1155/2018/6212410
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发表时间：
2018
影响因子：
4.1
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Chen X;Zhang JX;Shang WW;Xie WP;Jin SX;Wang F
古德综合征（GS）通常伴有反复呼吸道感染和慢性腹泻。主要目的是评估胸腺瘤切除术后GS患者的外周免疫状态。招募20名健康志愿者作为健康对照（HC）。应用流式细胞术测定GS患者外周血中CD 4 + T细胞、CD 8 + T细胞、γδT细胞和调节性T细胞的比例。检测了该例GS患者体外培养的CD 4 + T细胞增殖能力，并检测了其体外培养的免疫细胞分泌的细胞因子IFN-γ和IL-17 A的水平。与健康对照组相比，该GS患者外周血中B细胞较少，CD 4 +/CD 8+细胞比例倒置，Treg细胞较多。此外，尽管具有正常的γδT细胞百分比，但患者的Vδ2 T细胞水平显著降低。来自患者的离体外周CD 4 + T细胞显示出增殖和分裂潜力不足以及PD-1的过度表达。此外，在该GS患者中，IFN-γ主要来源于CD 8 + T细胞，而不是CD 4 + T细胞和γδT细胞。这个GS患者在胸腺切除术后有受损的T和B细胞免疫改变和细胞因子干扰。详细的研究应该集中在可以调整这些患者的免疫状态以获得更好结果的疗法上。
Good's syndrome (GS) is often accompanied by recurrent respiratory infections and chronic diarrhea. The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection. Twenty healthy volunteers were recruited as healthy controls (HCs). Flow cytometry was applied to determine the proportions of circuiting CD4+ T cells, CD8+ T cells, γδT cells, and regulatory T (Treg) cells in our GS patient. We also examined the proliferation capability of ex vivo CD4+ T cells and detected the levels of cytokines interferon- (IFN-) γ and interleukin-17A secreted by ex vivo immune cells from this GS patient. Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4+/CD8+ cells, and more Treg cells in his peripheral blood. Additionally, the patient's Vδ2 T cell levels were significantly decreased despite having a normal percentage of γδT cells. Ex vivo peripheral CD4+ T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1. Moreover, IFN-γ was predominantly derived from CD8+ T cells in this GS patient, rather than from CD4+ T cells and γδT cells. This GS patient had impaired T and B cell immunological alternations and cytokine disruptions after thymectomy. Detailed research should focus on therapies that can adjust the immune status in such patients for a better outcome.
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常见可变免疫缺陷患者的调节性T细胞频率降低。
影响因子：
3.7
作者：
Melo KM;Carvalho KI;Bruno FR;Ndhlovu LC;Ballan WM;Nixon DF;Kallas EG;Costa-Carvalho BT
通讯作者：
Costa-Carvalho BT
免疫系统状态和胸膜切除患者呼吸系统障碍的出现。
影响因子：
3.2
作者：
Krawczyk, Pawel;Adamczyk-Korbel, Marta;Kieszko, Robert;Korobowicz, Elzbieta;Milanowski, Janusz
通讯作者：
Milanowski, Janusz
DOI：
10.1016/j.clim.2008.12.006
发表时间：
2009-05
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Yu GP;Chiang D;Song SJ;Hoyte EG;Huang J;Vanishsarn C;Nadeau KC
通讯作者：
Nadeau KC
影响因子：
4.3
作者：
Arandi, Nargess;Mirshafiey, Abbas;Aghamohammadi, Asghar
通讯作者：
Aghamohammadi, Asghar
影响因子：
4.4
作者：
Wu, J;Groh, V;Spies, T
通讯作者：
Spies, T