Maternal programming of sexual attractivity in female Long Evans rats.
Maternal programming of sexual attractivity in female Long Evans rats.
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DOI：
10.1016/j.psyneuen.2011.02.016
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发表时间：
2011-09
影响因子：
3.7
通讯作者：
Francis, Darlene D.
中科院分区：
文献类型：
--
作者：
Sakhai, Samuel A.;Kriegsfeld, Lance J.;Francis, Darlene D.
关键词：
在哺乳动物中，母性照顾在多个领域影响着发育中的后代。例如，在朗埃文斯大鼠中，幼鼠接受的母性护理的质量会影响后来的认知功能、神经内分泌对压力的反应和情绪的行为测量。来自人类、非人类灵长类动物和啮齿类动物的数据也表明，早期生活事件可能类似地扰乱有性生殖的测量，可能对生殖健康产生影响。目前的研究考察了在不同母性条件下饲养的雄性同种动物是否会对雌性有不同的偏好（通过舔舐和梳理的数量来评估；LG）。此外，我们还量化了母性照顾对成年女性性动机和性行为的影响，以确定这些行为特征是否与观察到的任何偏好有关。在配偶偏好任务中，雄性大鼠几乎完全选择与低LG条件下饲养的雌性大鼠交配和射精。在无节奏交配条件下，雌性低LG大鼠的副种群行为和交配行为明显高于雌性高LG大鼠。由于黄体酮受体在雌性副种群行为中的关键作用，我们还对两组雌性大鼠下丘脑腹内侧核（VMH）的黄体酮受体免疫反应性（PR-ir）进行了评估。雌二醇诱导的低LG大鼠VMH PR-ir明显高于高LG大鼠。综上所述，这些数据表明，早期的父母抚育可能会影响成年女性的性吸引力和性行为，从而影响其行为和生理方面的发展。
In mammals, maternal care influences the developing offspring across multiple domains. In Long Evans rats, for example, the quality of maternal care received as a pup influences later cognitive function, neuroendocrine responses to stress and behavioral measures of emotionality. Data from humans, non-human primates, and rodents also suggest that early life events may similarly perturb measures of sexual reproduction, with possible consequences for reproductive fitness. The current study examined whether or not male conspecifics differentially prefer females, as adult mating partners, that were reared under varying maternal conditions (assessed via the quantity of licking and grooming received; LG). Additionally, the impact of maternal care on adult female sexual motivation and behavior were quantified to determine if these behavioral characteristics are associated with any preference observed. In a mate preference task, male rats chose, almost exclusively, to mount, copulate and ejaculate with female rats reared under Low LG conditions. Under non-paced mating conditions, female Low LG rats display significantly more paracopulatory and copulatory behaviors compared to High LG rats. Due to its critical role in female paracopulatory behavior, progesterone receptor immunoreactivity (PR-ir) in the ventromedial nucleus of the hypothalamus (VMH) was also assessed in both groups of female rats. Estradiol induced PR-ir in the VMH was significantly higher in Low LG relative to High LG rats. Together, these data suggests that early life parental care may developmentally program aspects of behavior and physiology that subsequently influence sexual attractivity and behavior in adult females.
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影响因子：
2.3
作者：
DANFORTH, BN
通讯作者：
DANFORTH, BN
影响因子：
2.2
作者：
COKER, AL;RICHTER, DL;VINCENT, ML
通讯作者：
VINCENT, ML
DOI：
10.1530/jrf.0.0900375
发表时间：
1990-11-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
FRYE, CA;ERSKINE, MS
通讯作者：
ERSKINE, MS
影响因子：
4
作者：
Gomes, CM;Raineki, C;Lucion, AB
通讯作者：
Lucion, AB
影响因子：
3.5
作者：
Blaustein JD;Farrell S;Ghavami G;Laroche J;Mohan G
通讯作者：
Mohan G