Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study.
Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study.
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DOI：
10.1007/s00394-020-02455-2
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发表时间：
2021-08
影响因子：
5
通讯作者：
Woodside JV
中科院分区：
文献类型：
--
作者：
McKay GJ;Lyner N;Linden GJ;Kee F;Moitry M;Biasch K;Amouyel P;Dallongeville J;Bongard V;Ferrières J;Gey KF;Patterson CC;Woodside JV
与冠心病（CHD）相关的主要潜在危险因素是可改变的，氧化损伤和全身炎症损伤是与冠心病的发生和进展以及过早死亡相关的关键病因学因素。研究血浆抗氧化状态与全因死亡率和致死性或非致死性心血管事件的关系。PRIME研究前瞻性地评估了1991年至1993年间北爱尔兰和法国的9709名年龄在50-59岁之间的男性，他们在招募时没有冠心病，每年随访10年，观察死亡和心血管事件。用高效液相色谱法测定血清中维生素C、视黄醇、两种维生素E （α-和γ-生育酚）和6种类胡萝卜素的浓度。通过Cox回归分析，考虑了基线常规风险因素，以及社会经济差异和生活方式行为，包括饮食、吸烟习惯、体育活动和饮酒。10年后，有538人死于任何原因，440人死于致命或非致命的心血管事件。在调整了国家、年龄、收缩压、糖尿病、体重指数、胆固醇、高密度脂蛋白胆固醇、甘油三酯、身高、总体力活动、饮酒和吸烟习惯等因素后，除γ-生育酚外，所有抗氧化剂水平越高，全因死亡率风险越低。在一个完全调整的模型中，只有视黄醇与心血管事件风险降低显著相关。低抗氧化剂水平导致了与生活方式行为、传统心血管和社会经济风险因素无关的全因死亡率和心血管发病率梯度。在线版本包含补充材料，可在10.1007/s00394-020-02455-2获得。
The main underlying risk factors associated with coronary heart disease (CHD) are modifiable and oxidative injury and systemic inflammatory damage represent key aetiological factors associated with the development and progression of CHD and premature mortality. To examine associations of plasma antioxidant status with all-cause mortality and fatal or non-fatal cardiovascular events. The PRIME study prospectively evaluated 9709 men aged 50–59 years between 1991 and 1993 in Northern Ireland and France who were free of CHD at recruitment and followed annually for deaths and cardiovascular events for 10 years. Serum concentrations of vitamin C, retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography. Baseline conventional risk factors were considered, as well as socioeconomic differences and lifestyle behaviours including diet, smoking habit, physical activity, and alcohol consumption through Cox regression analyses. At 10 years, there were 538 deaths from any cause and 440 fatal or non-fatal cardiovascular events. After adjustment for country, age, systolic blood pressure, diabetes, body mass index, cholesterol, high density lipoprotein cholesterol, triglycerides, height, total physical activity, alcohol consumption and smoking habit, higher levels of all antioxidants were associated with significantly lower risk of all-cause mortality, with the exception of γ-tocopherol. Only retinol was significantly associated with decreased risk of cardiovascular events in a fully adjusted model. Low antioxidant levels contribute to the gradient of all-cause mortality and cardiovascular incidence independent of lifestyle behaviours and traditional cardiovascular and socioeconomic risk factors. The online version contains supplementary material available at 10.1007/s00394-020-02455-2.
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DOI：
10.1093/ajcn/nqy097
发表时间：
2018-11-01
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1158/1055-9965.epi-13-0381
发表时间：
2013-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Goyal A;Terry MB;Siegel AB
通讯作者：
Siegel AB
影响因子：
24
作者：
Libby P
通讯作者：
Libby P
影响因子：
7.1
作者：
GEY, KF;BRUBACHER, GB;STAHELIN, HB
通讯作者：
STAHELIN, HB
DOI：
10.1016/0005-2760(91)90164-d
发表时间：
1991-10-15
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
JIALAL, I;NORKUS, EP;GRUNDY, SM
通讯作者：
GRUNDY, SM