Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
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DOI：
10.1093/ajcn/nqy097
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发表时间：
2018-11-01
期刊：
影响因子：
--
通讯作者：
Norat T
中科院分区：
文献类型：
--
作者：
Aune D;Keum N;Giovannucci E;Fadnes LT;Boffetta P;Greenwood DC;Tonstad S;Vatten LJ;Riboli E;Norat T
维生素C、类胡萝卜素和维生素E的高膳食摄入量或血液浓度（作为膳食摄入的生物标志物）与心血管疾病、癌症和死亡率的风险降低有关，但这些相关性尚未得到系统评估。我们对维生素C、类胡萝卜素和维生素E的膳食摄入量和血液浓度与这些结果相关的前瞻性研究进行了系统回顾和荟萃分析。我们检索了截至2018年2月14日的PubMed和Embase。使用随机效应模型计算总结RR和95% CI。纳入了69项前瞻性研究（99篇出版物）。每增加100 mg/d膳食维生素C摄入量的总RR为0.88（95% CI：0.79，0.98，I2 = 65%，n = 11）冠心病，0.92（95% CI：0.87，0.98，I2 = 68%，n = 12）卒中，0.89（95% CI：0.85，0.94，I2 = 27%，n = 10）对于心血管疾病，0.93对于总癌症（95% CI：0.87，0.99，I2 = 46%，n = 8），对于全因死亡率为0.89（95% CI：0.85，0.94，I2 = 80%，n = 14）。维生素C血药浓度每增加50 μmol/L的相应RR为0.74（95% CI：0.65，0.83，I2 = 0%，n = 4），0.70（95% CI：0.61，0.81，I2 = 0%，n = 4），0.76（95% CI：0.65，0.87，I2 = 56%，n = 6）、0.74（95% CI：0.66，0.82，I2 = 0%，n = 5）和0.72（95% CI：0.66，0.79，I2 = 0%，n = 8）。膳食摄入和/或血中类胡萝卜素（总胡萝卜素、β-胡萝卜素、α-胡萝卜素、β-隐黄素、番茄红素）和α-生育酚的浓度，而不是膳食维生素E，与冠心病、中风、心血管疾病、癌症和/或全因死亡率呈类似的负相关。较高的膳食摄入量和/或维生素C、类胡萝卜素和α-生育酚（作为水果和蔬菜摄入量的标志物）的血液浓度与心血管疾病、总癌症和全因死亡率的风险降低相关。这些结果支持增加水果和蔬菜摄入量的建议，而不是抗氧化剂补充剂的使用，以预防慢性病。
High dietary intake or blood concentrations (as biomarkers of dietary intake) of vitamin C, carotenoids, and vitamin E have been associated with reduced risk of cardiovascular disease, cancer, and mortality, but these associations have not been systematically assessed. We conducted a systematic review and meta-analysis of prospective studies of dietary intake and blood concentrations of vitamin C, carotenoids, and vitamin E in relation to these outcomes. We searched PubMed and Embase up to 14 February 2018. Summary RRs and 95% CIs were calculated with the use of random-effects models. Sixty-nine prospective studies (99 publications) were included. The summary RR per 100-mg/d increment of dietary vitamin C intake was 0.88 (95% CI: 0.79, 0.98, I2 = 65%, n = 11) for coronary heart disease, 0.92 (95% CI: 0.87, 0.98, I2 = 68%, n = 12) for stroke, 0.89 (95% CI: 0.85, 0.94, I2 = 27%, n = 10) for cardiovascular disease, 0.93 (95% CI: 0.87, 0.99, I2 = 46%, n = 8) for total cancer, and 0.89 (95% CI: 0.85, 0.94, I2 = 80%, n = 14) for all-cause mortality. Corresponding RRs per 50-μmol/L increase in blood concentrations of vitamin C were 0.74 (95% CI: 0.65, 0.83, I2 = 0%, n = 4), 0.70 (95% CI: 0.61, 0.81, I2 = 0%, n = 4), 0.76 (95% CI: 0.65, 0.87, I2 = 56%, n = 6), 0.74 (95% CI: 0.66, 0.82, I2 = 0%, n = 5), and 0.72 (95% CI: 0.66, 0.79, I2 = 0%, n = 8). Dietary intake and/or blood concentrations of carotenoids (total, β-carotene, α-carotene, β-cryptoxanthin, lycopene) and α-tocopherol, but not dietary vitamin E, were similarly inversely associated with coronary heart disease, stroke, cardiovascular disease, cancer, and/or all-cause mortality. Higher dietary intake and/or blood concentrations of vitamin C, carotenoids, and α-tocopherol (as markers of fruit and vegetable intake) were associated with reduced risk of cardiovascular disease, total cancer, and all-cause mortality. These results support recommendations to increase fruit and vegetable intake, but not antioxidant supplement use, for chronic disease prevention.
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影响因子：
4.2
作者：
Del Rio, Daniele;Agnoli, Claudia;Panico, Salvatore
通讯作者：
Panico, Salvatore
影响因子：
9.3
作者：
Bøhn SK;Myhrstad MC;Thoresen M;Holden M;Karlsen A;Tunheim SH;Erlund I;Svendsen M;Seljeflot I;Moskaug JO;Duttaroy AK;Laake P;Arnesen H;Tonstad S;Collins A;Drevon CA;Blomhoff R
通讯作者：
Blomhoff R
影响因子：
4.7
作者：
Al-Delaimy, WK;Ferrari, P;Riboli, E
通讯作者：
Riboli, E
影响因子：
4.2
作者：
Buijsse, Brian;Feskens, Edith J. M.;Kromhout, Daan
通讯作者：
Kromhout, Daan
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N