Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression.
Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression.
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DOI：
10.3389/fphys.2014.00052
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发表时间：
2014
影响因子：
4
通讯作者：
Apte MV
中科院分区：
文献类型：
--
作者：
Wilson JS;Pirola RC;Apte MV
胰腺癌是一种毁灭性的疾病，其死亡率与发病率之比高得令人无法接受。传统的治疗方法，如手术联合化疗或放疗，在改善这种疾病的结果方面疗效有限。直到不到十年前，作为大多数胰腺导管腺癌（PDAC）特征的突出促纤维增生反应在很大程度上被忽视。然而，由于胰腺星状细胞（PSC）作为负责PDAC中胶原基质产生的关键细胞的鉴定，基质反应在胰腺癌病理生物学中的作用受到越来越多的关注。现在有令人信服的证据表明，PSC不仅与癌细胞本身相互作用，而且与基质中的其他几种细胞类型（内皮细胞，免疫细胞和可能的神经元细胞）相互作用，以促进癌症进展。本文综述了PSC和间质微环境对癌症行为的影响，并讨论了新的治疗方法，这些方法反映了临床医生和研究人员越来越多的认识，即单独靶向癌细胞不再足以改善患者的预后，需要靶向间质和癌细胞的组合治疗来改变这一临床过程。疾病
Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence ratio. Traditional therapeutic approaches such as surgery in combination with chemo- or radiotherapy have had limited efficacy in improving the outcome of this disease. Up until just under a decade ago, the prominent desmoplastic reaction which is a characteristic of the majority of pancreatic ductal adenocarcinomas (PDAC) had been largely ignored. However, since the identification of the pancreatic stellate cell (PSC) as the key cell responsible for the production of the collagenous stroma in PDAC, increasing attention has been paid to the role of the stromal reaction in pancreatic cancer pathobiology. There is now compelling evidence that PSCs interact not only with cancer cells themselves, but with several other cell types in the stroma (endothelial cells, immune cells, and possibly neuronal cells) to promote cancer progression. This review summarizes current knowledge in the field about the influence of PSCs and the stromal microenvironment on cancer behavior and discusses novel therapeutic approaches which reflect an increasing awareness amongst clinicians and researchers that targeting cancer cells alone is no longer sufficient to improve patient outcome and that combinatorial treatments targeting the stroma as well as the cancer cells will be required to change the clinical course of this disease.
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影响因子：
29.4
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
通讯作者：
Pandol SJ
肿瘤微环境中的肥大细胞促进了胰腺导管腺癌的体内生长。
DOI：
10.1158/1078-0432.ccr-11-0607
发表时间：
2011-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chang DZ;Ma Y;Ji B;Wang H;Deng D;Liu Y;Abbruzzese JL;Liu YJ;Logsdon CD;Hwu P
通讯作者：
Hwu P
影响因子：
4
作者：
Apte MV;Pirola RC;Wilson JS
通讯作者：
Wilson JS
影响因子：
29.4
作者：
Ceyhan, Gueralp O.;Bergmann, Frank;Friess, Helmut
通讯作者：
Friess, Helmut
影响因子：
7.5
作者：
Fukushima, Noriyoshi;Kikuchi, Yoshinao;Fukayama, Masashi
通讯作者：
Fukayama, Masashi