Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits.
Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits.
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DOI：
10.1002/ajmg.b.32922
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发表时间：
2023-01
期刊：
影响因子：
--
通讯作者：
Middeldorp CM
中科院分区：
文献类型：
--
作者：
Akingbuwa WA;Hammerschlag AR;Allegrini AG;Sallis H;Kuja-Halkola R;Rimfeld K;Lichtenstein P;Lundstrom S;Munafò MR;Plomin R;Nivard MG;Bartels M;Middeldorp CM
无处不在的协会已被检测到不同类型的儿童期精神病理学和多基因风险评分的基础上成人精神疾病和相关的成人结果，表明遗传因素部分解释儿童期精神病理学和成人结果之间的关联。然而，这些分析一般不考虑成人性状和疾病多基因风险评分之间的相关性。本研究旨在通过解释这些相关性，进一步阐明遗传因素对儿童期精神病理学和成人结局之间关联的影响。使用多变量多变量回归，我们分析了儿童注意力缺陷多动障碍（ADHD），内化和社会问题与成人疾病和特征的多基因评分（PGS）的关系，包括重度抑郁症，双相情感障碍，主观幸福感，神经质，失眠，教育程度和体重指数（BMI），来自20，539名8.5-10.5岁的儿童。在校正成人表型之间的相关性后，重度抑郁症PGS与所有三个儿童特征，即ADHD，内化和社会问题有关。此外，BMI PGS与ADHD症状和社会问题相关，而神经质PGS仅与内化问题相关，教育程度PGS仅与ADHD症状相关。双相情感障碍、主观幸福感和失眠的PGS与任何儿童特征无关。我们的研究结果表明，儿童精神病理学与失眠和主观幸福感等成人特征之间的关联可能主要是由影响成人重度抑郁症的遗传因素驱动的。此外，特定的儿童表型与教育程度、BMI和神经质有遗传相关性。
Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not take into account the correlations between the adult trait and disorder polygenic risk scores. This study aimed to further clarify the influence of genetic factors on associations between childhood psychopathology and adult outcomes by accounting for these correlations. Using a multivariate multivariable regression, we analyzed associations of childhood attention-deficit/hyperactivity disorder (ADHD), internalizing, and social problems, with polygenic scores (PGS) of adult disorders and traits including major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI), derived for 20,539 children aged 8.5–10.5 years. After correcting for correlations between the adult phenotypes, major depression PGS were associated with all three childhood traits, that is, ADHD, internalizing, and social problems. In addition, BMI PGS were associated with ADHD symptoms and social problems, while neuroticism PGS were only associated with internalizing problems and educational attainment PGS were only associated with ADHD symptoms. PGS of bipolar disorder, subjective well-being, and insomnia were not associated with any childhood traits. Our findings suggest that associations between childhood psychopathology and adult traits like insomnia and subjective well-being may be primarily driven by genetic factors that influence adult major depression. Additionally, specific childhood phenotypes are genetically associated with educational attainment, BMI and neuroticism.
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影响因子：
7.6
作者：
Kwong, Alex S. F.;Morris, Tim T.;Tilling, Kate
通讯作者：
Tilling, Kate
影响因子：
30.8
作者：
Cai N;Revez JA;Adams MJ;Andlauer TFM;Breen G;Byrne EM;Clarke TK;Forstner AJ;Grabe HJ;Hamilton SP;Levinson DF;Lewis CM;Lewis G;Martin NG;Milaneschi Y;Mors O;Müller-Myhsok B;Penninx BWJH;Perlis RH;Pistis G;Potash JB;Preisig M;Shi J;Smoller JW;Streit F;Tiemeier H;Uher R;Van der Auwera S;Viktorin A;Weissman MM;MDD Working Group of the Psychiatric Genomics Consortium;Kendler KS;Flint J
通讯作者：
Flint J
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
儿童期和青少年抑郁症与成人精神病和功能结果的关联。
DOI：
10.1016/j.jaac.2020.07.895
发表时间：
2021-05
影响因子：
13.3
作者：
Copeland WE;Alaie I;Jonsson U;Shanahan L
通讯作者：
Shanahan L
DOI：
10.1016/j.bpsc.2017.11.013
发表时间：
2018-07
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Du Rietz E;Coleman J;Glanville K;Choi SW;O'Reilly PF;Kuntsi J
通讯作者：
Kuntsi J