Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy.
Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy.
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神经肽 Y 对干细胞的影响及其在疾病治疗中的潜在应用
DOI：
10.1155/2017/6823917
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发表时间：
2017
影响因子：
4.3
通讯作者：
Lin S
中科院分区：
文献类型：
--
作者：
Peng S;Zhou YL;Song ZY;Lin S
神经肽Y（NPY）是一种36个氨基酸的肽，广泛分布于中枢和周围神经系统以及其他外周组织中。它参与调节食物摄入、昼夜节律、能量代谢和神经内分泌分泌等多种生物过程。越来越多的证据表明 NPY 对干细胞发挥多种调节作用。干细胞作为一种原始的、未分化的细胞，具有替代受损细胞、分泌旁分泌分子、促进血管生成、调节免疫等治疗潜力。基于干细胞的疗法已被证明是有效的，并被认为是针对特定疾病最有前途的治疗方法之一。然而，一些限制仍然阻碍其应用，例如移植干细胞的存活率低、分化和整合率低。 NPY对干细胞存活、增殖和分化的调节作用可能有助于克服这些限制并促进基于干细胞的治疗的应用。在这篇综述中，我们总结了 NPY 对干细胞的调节作用，并讨论了它们在疾病治疗中的潜在应用。
Neuropeptide Y (NPY), a 36-amino acid peptide, is widely distributed in the central and peripheral nervous systems and other peripheral tissues. It takes part in regulating various biological processes including food intake, circadian rhythm, energy metabolism, and neuroendocrine secretion. Increasing evidence indicates that NPY exerts multiple regulatory effects on stem cells. As a kind of primitive and undifferentiated cells, stem cells have the therapeutic potential to replace damaged cells, secret paracrine molecules, promote angiogenesis, and modulate immunity. Stem cell-based therapy has been demonstrated effective and considered as one of the most promising treatments for specific diseases. However, several limitations still hamper its application, such as poor survival and low differentiation and integration rates of transplanted stem cells. The regulatory effects of NPY on stem cell survival, proliferation, and differentiation may be helpful to overcome these limitations and facilitate the application of stem cell-based therapy. In this review, we summarized the regulatory effects of NPY on stem cells and discussed their potential applications in disease therapy.
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影响因子：
3.7
作者：
Corvino V;Marchese E;Podda MV;Lattanzi W;Giannetti S;Di Maria V;Cocco S;Grassi C;Michetti F;Geloso MC
通讯作者：
Geloso MC
影响因子：
3.6
作者：
Baker SB;Cohen M;Kuo L;Johnson M;Al-Attar A;Zukowska Z
通讯作者：
Zukowska Z
影响因子：
--
作者：
BILLINGTON, CJ;BRIGGS, JE;LEVINE, AS
通讯作者：
LEVINE, AS
影响因子：
4.7
作者：
Alvaro, Ana Rita;Rosmaninho-Salgado, Joana;Cavadas, Claudia
通讯作者：
Cavadas, Claudia
影响因子：
5.8
作者：
Cavadas, C;Silva, AP;Grouzmann, E
通讯作者：
Grouzmann, E