Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.
Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.
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DOI：
10.1021/acsinfecdis.7b00183
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发表时间：
2018-03-09
影响因子：
5.3
通讯作者：
Townsend SD
中科院分区：
文献类型：
--
作者：
Ackerman DL;Craft KM;Doster RS;Weitkamp JH;Aronoff DM;Gaddy JA;Townsend SD
在之前的研究中，我们报道了从五个供者乳样中分离的人乳寡糖(HMOS)对无乳链球菌(又称B组链球菌或GBS)具有抗菌和抗生物膜活性。在此，我们通过筛选14个新捐赠者的HMO来对抗三种GBS菌株和两种与儿童健康特别相关的ESKAPE病原体，即金黄色葡萄球菌和鲍曼不动杆菌，对其抗菌和抗生物被膜活性进行了更广泛的评估。生长和生物被膜实验表明，来自这些新供体的HMOS对所有三株GBS都具有抗菌和抗生物膜活性，对耐甲氧西林金黄色葡萄球菌USA300具有抗生物膜活性，对鲍曼不动杆菌ATCC 19606具有抗菌活性。
In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.
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影响因子：
2.1
作者：
Maxson T;Mitchell DA
通讯作者：
Mitchell DA
影响因子：
5.3
作者：
Craft KM;Townsend SD
通讯作者：
Townsend SD
影响因子：
4.7
作者：
Asakuma, S.;Urashima, T.;Sanai, Y.
通讯作者：
Sanai, Y.
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John
影响因子：
2.9
作者：
Cotton, Jennifer L.;Tao, Jianshi;Balibar, Carl J.
通讯作者：
Balibar, Carl J.