Losartan chemistry and its effects via AT1 mechanisms in the kidney.
Losartan chemistry and its effects via AT1 mechanisms in the kidney.
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DOI：
10.2174/092986709789105000
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发表时间：
2009
影响因子：
4.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Xu F;Mao C;Liu Y;Wu L;Xu Z;Zhang L
除了肾素-血管紧张素系统（RAS）在循环和其他器官中的重要性外，肾脏局部RAS的研究也引起了人们的极大关注。肾脏RAS在体液平衡和心血管长期调节中起重要作用。所有主要成分和关键酶的建立一个本地的RAS以及两个重要的血管紧张素II（Ang II）受体亚型，AT 1和AT 2受体，已被证实在肾脏。除了肾脏对全身RAS的贡献外，肾内RAS在肾功能调节以及肾脏疾病的发展中起关键作用。值得注意的是，位于肾内不同细胞和隔室的肾AT 1受体对于正常的肾生理功能和异常的病理生理过程是重要的。这篇迷你评论的重点是：1）局部肾RAS及其受体，特别是AT 1受体及其在生理和病理生理过程中的机制，和2）选择性AT 1受体阻断剂氯沙坦的化学，及其在肾RAS介导的疾病中的作用的潜在机制。
Besides the importance of the renin-angiotensin system (RAS) in the circulation and other organs, the local RAS in the kidney has attracted a great attention in research in last decades. The renal RAS plays an important role in the body fluid homeostasis and long-term cardiovascular regulation. All major components and key enzymes for the establishment of a local RAS as well as two important angiotensin II (Ang II) receptor subtypes, AT1 and AT2 receptors, have been confirmed in the kidney. In addition to renal contribution to the systemic RAS, the intrarenal RAS plays a critical role in the regulation of renal function as well as in the development of kidney disease. Notably, kidney AT1 receptors located at different cells and compartments inside the kidney are important for normal renal physiological functions and abnormal pathophysiological processes. This mini-review focuses on: 1) the local renal RAS and its receptors, particularly the AT1 receptor and its mechanisms in physiological and pathophysiological processes, and 2) the chemistry of the selective AT1 receptor blocker, losartan, and the potential mechanisms for its actions in the renal RAS-mediated disease.
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影响因子：
4.9
作者：
Davis, BJ;Cao, ZM;Allen, TJ
通讯作者：
Allen, TJ
影响因子：
8.3
作者：
Border, WA;Noble, NA
通讯作者：
Noble, NA
影响因子：
8.3
作者：
BRAAM, B;NAVAR, LG;MITCHELL, KD
通讯作者：
MITCHELL, KD
影响因子：
3.1
作者：
Abrahamsen, CT;Pullen, M;Brooks, DP
通讯作者：
Brooks, DP
影响因子：
3.6
作者：
DARBY, IA;SERNIA, C
通讯作者：
SERNIA, C