Microglia states and nomenclature: A field at its crossroads.
Microglia states and nomenclature: A field at its crossroads.
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DOI：
10.1016/j.neuron.2022.10.020
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发表时间：
2022-11-02
期刊：
影响因子：
16.2
通讯作者：
Wyss-Coray, Tony
中科院分区：
文献类型：
--
作者：
Paolicelli, Rosa C.;Sierra, Amanda;Stevens, Beth;Tremblay, Marie-Eve;Aguzzi, Adriano;Ajami, Bahareh;Amit, Ido;Audinat, Etienne;Bechmann, Ingo;Bennett, Mariko;Bennett, Frederick;Bessis, Alain;Biber, Knut;Bilbo, Staci;Blurton-Jones, Mathew;Boddeke, Erik;Brites, Dora;Brone, Bert;Brown, Guy C.;Butovsky, Oleg;Carson, Monica J.;Castellano, Bernardo;Colonna, Marco;Cowley, Sally A.;Cunningham, Colm;Davalos, Dimitrios;De Jager, Philip L.;de Strooper, Bart;Denes, Adam;Eggen, Bart J. L.;Eyo, Ukpong;Galea, Elena;Garel, Sonia;Ginhoux, Florent;Glass, Christopher K.;Gokce, Ozgun;Gomez-Nicola, Diego;Gonzalez, Berta;Gordon, Siamon;Graeber, Manuel B.;Greenhalgh, Andrew D.;Gressens, Pierre;Greter, Melanie;Gutmann, David H.;Haass, Christian;Heneka, Michael T.;Heppner, Frank L.;Hong, Soyon;Hume, David A.;Jung, Steffen;Kettenmann, Helmut;Kipnis, Jonathan;Koyama, Ryuta;Lemke, Greg;Lynch, Marina;Majewska, Ania;Malcangio, Marzia;Malm, Tarja;Mancuso, Renzo;Masuda, Takahiro;Matteoli, Michela;McColl, Barry W.;Miron, Veronique E.;Molofsky, Anna Victoria;Monje, Michelle;Mracsko, Eva;Nadjar, Agnes;Neher, Jonas J.;Neniskyte, Urte;Neumann, Harald;Noda, Mami;Peng, Bo;Peri, Francesca;Perry, V. Hugh;Popovich, Phillip G.;Pridans, Clare;Priller, Josef;Prinz, Marco;Ragozzino, Davide;Ransohoff, Richard M.;Salter, Michael W.;Schaefer, Anne;Schafer, Dorothy P.;Schwartz, Michal;Simons, Mikael;Smith, Cody J.;Streit, Wolfgang J.;Tuan Leng Tay;Tsai, Li-Huei;Verkhratsky, Alexei;von Bernhardi, Rommy;Wake, Hiroaki;Wittamer, Valerie;Wolf, Susanne A.;Wu, Long-Jun;Wyss-Coray, Tony
近几十年来，小胶质细胞研究取得了长足进展，但也受到一系列连续出现的二分法的限制，比如“静息态与激活态”以及“M1型与M2型”。这种对小胶质细胞好或坏的二元分类与近年来所阐明的小胶质细胞在发育、可塑性、衰老和疾病中的多种状态和功能不一致。为了描述不同的小胶质细胞状态而不断出现的新名称（尤其是通过转录组学和蛋白质组学定义的）可能很容易导致类别和功能之间产生误导性（尽管是无意的）关联。为了解决这些问题，我们召集了一组多学科专家来讨论我们目前对作为一个动态概念的小胶质细胞状态的理解以及解决小胶质细胞功能的重要性。在此，我们为研究人员、审稿人和编辑提供了一个关于小胶质细胞命名法使用的概念框架和建议，这将作为未来白皮书的基础。
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated” and “M1 versus M2.” This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
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影响因子：
9.8
作者：
Abiega O;Beccari S;Diaz-Aparicio I;Nadjar A;Layé S;Leyrolle Q;Gómez-Nicola D;Domercq M;Pérez-Samartín A;Sánchez-Zafra V;Paris I;Valero J;Savage JC;Hui CW;Tremblay MÈ;Deudero JJ;Brewster AL;Anderson AE;Zaldumbide L;Galbarriatu L;Marinas A;Vivanco MD;Matute C;Maletic-Savatic M;Encinas JM;Sierra A
通讯作者：
Sierra A
影响因子：
3.2
作者：
ACARIN, L;VELA, JM;CASTELLANO, B
通讯作者：
CASTELLANO, B
影响因子：
5.3
作者：
Avignone, Elena;Ulmann, Lauriane;Audinat, Etienne
通讯作者：
Audinat, Etienne
影响因子：
46.9
作者：
Bartosovic M;Kabbe M;Castelo-Branco G
通讯作者：
Castelo-Branco G
影响因子：
3.2
作者：
CASTELLANO, B;GONZALEZ, B;ZIMMER, J
通讯作者：
ZIMMER, J