Extended healing validation of an artificial tendon to connect the quadriceps muscle to the Tibia: 180-day study.
Extended healing validation of an artificial tendon to connect the quadriceps muscle to the Tibia: 180-day study.
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DOI：
10.1002/jor.22043
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发表时间：
2012-07
影响因子：
2.8
通讯作者：
Juncosa-Melvin, Natalia
中科院分区：
文献类型：
--
作者：
Melvin, Alan J.;Litsky, Alan S.;Mayerson, Joel L.;Stringer, Keith;Juncosa-Melvin, Natalia
每当肌腱或其骨骼插入被破坏或移除时，现有的手术技术就会提供临时连接或支架来促进愈合，但如果生物材料与非生物材料的界面必须承受载荷，那么它很快就会在这些应用的压力下发生分解。超过剧烈的。因此，患者残疾，其假体，缺陷大小，或仅仅是解剖结构限制了这种治疗的可用性或结果。我们的团队开发了OrthoCoupler™器械，用于将骨骼肌连接到假体或自然结构，而不会发生这种界面破坏。在这项研究中，山羊膝关节伸肌机制（股四头肌腱，髌骨，髌腱）从16只山羊的右后肢。该器械将股四头肌连接到胫骨上的不锈钢接骨板上。在180天时，从每条手术腿和对侧未手术对照腿收集机械测试和组织学标本。手术腿（与未手术腿相比）的最大力为1400± 93 N（与1179± 61 N），线性刚度为33± 3 N/mm（与37 ± 4 N/mm），失效伸长率为92.1 ± 5.3 mm（与68.4 ± 3.8 mm;平均值± SEM）。与未手术对照组相比，使用器械的腿的最大力（p = 0.02）和失效伸长率（p = 0.008）更高，具有显著性;线性刚度则无显著性（p = 0.3）。我们相信这项技术将为骨科肿瘤学、关节翻修术、肌腱转移和肌腱损伤重建的临床挑战带来改进的手术。
Whenever a tendon or its bone insertion is disrupted or removed, existing surgical techniques provide a temporary connection or scaffolding to promote healing, but the interface of living to nonliving materials soon breaks down under the stress of these applications, if it must bear the load more than acutely. Patients are thus disabled whose prostheses, defect size, or mere anatomy limit the availability or outcomes of such treatments. Our group developed the OrthoCoupler™ device to join skeletal muscle to prosthetic or natural structures without this interface breakdown. In this study, the goat knee extensor mechanism (quadriceps tendon, patella, and patellar tendon) was removed from the right hind limb in 16 goats. The device connected the quadriceps muscle to a stainless steel bone plate on the tibia. Mechanical testing and histology specimens were collected from each operated leg and contra lateral unoperated control legs at 180 days. Maximum forces in the operated leg (vs. unoperated) were 1400± 93N (vs. 1179± 61 N), linear stiffnesses were 33± 3 N/mm (vs. 37 ± 4N/mm), and elongations at failure were 92.1 ± 5.3 mm (vs. 68.4 ± 3.8 mm; mean ± SEM). Higher maximum forces (p = 0.02) and elongations at failure (p = 0.008) of legs with the device versus unoperated controls were significant; linear stiffnesses were not (p = 0.3). We believe this technology will yield improved procedures for clinical challenges in orthopaedic oncology, revision arthroplasty, tendon transfer, and tendon injury reconstruction.
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DOI：
10.3109/17453679909000997
发表时间：
1999-10-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
Ozaki, T;Kunisada, T;Inoue, H
通讯作者：
Inoue, H
影响因子：
2.4
作者：
Trumble, DR;Melvin, DB;Magovern, JA
通讯作者：
Magovern, JA
影响因子：
2.8
作者：
Melvin, Alan;Litsky, Alan;Mayerson, Joel;Witte, David;Melvin, David;Juncosa-Melvin, Natalia
通讯作者：
Juncosa-Melvin, Natalia
影响因子：
4.2
作者：
Melvin, DB;Klosterman, B;Clarson, SJ
通讯作者：
Clarson, SJ
影响因子：
1.7
作者：
Scott, AC;Chambers, C;Cain, TE
通讯作者：
Cain, TE