Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age.
Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age.
复制标题
随着年龄的增长，投射到听觉丘脑的下丘细胞越来越多地被神经元周网包围。
DOI：
10.1016/j.neurobiolaging.2021.04.001
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Mellott JG
中科院分区：
文献类型：
--
作者：
Mafi AM;Russ MG;Hofer LN;Pham VQ;Young JW;Mellott JG
年龄相关的下丘（IC）中GABA的损失可能在年龄相关性听力损失的发展中起作用。神经元周网（PN），细胞外基质的专门聚集体，随着年龄的增加，在IC。与GABA能神经传递相关的PNs可以稳定突触并抑制结构可塑性。我们试图确定投射到内侧膝状体（MG）的GABA能和非GABA能IC细胞上的PN表达是否增加。我们使用逆行追踪结合免疫组化谷氨酸脱羧酶和紫藤花凝集素在三个年龄组的Fischer Brown挪威大鼠。结果表明，在丘系和非丘系IC-MG细胞上，PN随年龄增加，但存在两个关键差异。首先，PN增加非丘系IC-MG细胞在中年，但直到老年丘系IC-MG细胞。其次，丘系IC-MG细胞上PN的增加发生在非GABA能细胞上，而不是GABA能细胞上。这些结果表明，突触稳定和可塑性降低可能发生在不同年龄的一个子集的IC-MG途径。
The age-related loss of GABA in the inferior colliculus (IC) likely plays a role in the development of age-related hearing loss. Perineuronal nets (PNs), specialized aggregates of extracellular matrix, increase with age in the IC. PNs, associated with GABAergic neurotransmission, can stabilize synapses and inhibit structural plasticity. We sought to determine whether PN expression increased on GABAergic and non-GABAergic IC cells that project to the medial geniculate body (MG). We used retrograde tract-tracing in combination with immunohistochemistry for glutamic acid decarboxylase and Wisteria floribunda agglutinin across three age groups of Fischer Brown Norway rats. Results demonstrate that PNs increase with age on lemniscal and non-lemniscal IC-MG cells, however two key differences exist. First, PNs increased on non-lemniscal IC-MG cells during middle-age, but not until old age on lemniscal IC-MG cells. Second, increases of PNs on lemniscal IC-MG cells occurred on non-GABAergic cells rather than on GABAergic cells. These results suggest that synaptic stabilization and reduced plasticity likely occur at different ages on a subset of the IC-MG pathway.
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影响因子：
4.2
作者：
Cai R;Montgomery SC;Graves KA;Caspary DM;Cox BC
通讯作者：
Cox BC
影响因子：
3.3
作者：
Bukalo, O;Schachner, M;Dityatev, A
通讯作者：
Dityatev, A
影响因子：
2.8
作者：
Brückner, G;Grosche, J;Schachner, M
通讯作者：
Schachner, M
影响因子：
3.3
作者：
Caspary, DM;Holder, TM;Naritoku, DK
通讯作者：
Naritoku, DK
影响因子：
3.4
作者：
Cisneros-Franco JM;Ouellet L;Kamal B;de Villers-Sidani E
通讯作者：
de Villers-Sidani E