Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome.

Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome.
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DOI:
10.1016/j.autneu.2021.102886
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发表时间:
2021-12
期刊:
Autonomic neuroscience : basic & clinical
影响因子:
--
通讯作者:
Furlan R
Furlan R
中科院分区:
其他
文献类型:
--
作者:
Diedrich A;Urechie V;Shiffer D;Rigo S;Minonzio M;Cairo B;Smith EC;Okamoto LE;Barbic F;Bisoglio A;Porta A;Biaggioni I;Furlan R

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体位性心动过速综合征(POTS)是一种慢性疾病,其特征在于直立不耐受的症状,例如疲劳、头晕、头晕、心悸、呼吸困难、胸部不适和站立时的显著心动过速。非侵入性经皮迷走神经刺激器已被应用于癫痫、焦虑、抑郁、头痛和慢性疼痛综合征的治疗。经皮迷走神经刺激后的抗炎和免疫调节作用引起了人们对其他疾病应用的兴趣。交感神经过度活跃、心脏迷走神经驱动减少和存在全身性炎症(如POTS)的患者可能受益于tVNS。本文将解决关键的方法方面的tVNS,并提供其急性和慢性使用POTS的初步结果,关于其潜在的有效性自主症状减少和心率调节。
Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations, dyspnea, chest discomfort and remarkable tachycardia upon standing. Non-invasive transdermal vagal stimulators have been applied for the treatment of epilepsy, anxiety, depression, headache, and chronic pain syndromes. Anti-inflammatory and immunomodulating effects after transdermal vagal stimulation raised interest for applications in other diseases. Patients with sympathetic overactivity, reduced cardiac vagal drive and presence of systemic inflammation like POTS may benefit from tVNS. This article will address crucial methodological aspects of tVNS and provide preliminary results of its acute and chronic use in POTS, with regards to its potential effectiveness on autonomic symptoms reduction and heart rate modulation.
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