An olfactory subsystem that mediates high-sensitivity detection of volatile amines.
An olfactory subsystem that mediates high-sensitivity detection of volatile amines.
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DOI：
10.1016/j.celrep.2012.06.006
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发表时间：
2012-07-26
期刊：
影响因子：
8.8
通讯作者：
Bozza T
中科院分区：
文献类型：
--
作者：
Pacifico R;Dewan A;Cawley D;Guo C;Bozza T
Olfactory stimuli are detected by over 1,000 odorant receptor genes in mice, with each receptor being mapped to specific glomeruli in the olfactory bulb. The Trace Amine-Associated Receptors (TAARs) are a small family of evolutionarily conserved olfactory receptors whose contribution to olfaction remains enigmatic. Here, we show that a majority of the TAARs are mapped to a discrete subset of glomeruli in the dorsal olfactory bulb of the mouse. This TAAR projection is distinct from the previously described class I and class II domains, and is formed by a sensory neuron population that is restricted to express TAAR genes prior to choice. We further show that the dorsal TAAR glomeruli are selectively activated by low concentrations of amines. Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines.
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影响因子：
2.5
作者：
Matsumoto, Hideyuki;Kobayakawa, Ko;Mori, Kensaku
通讯作者：
Mori, Kensaku
DOI：
10.1073/pnas.1117491109
发表时间：
2012-04-03
影响因子：
11.1
作者：
Ma, Limei;Qiu, Qiang;Yu, C. Ron
通讯作者：
Yu, C. Ron
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影响因子：
3.6
作者：
Bunzow, JR;Sonders, MS;Grandy, DK
通讯作者：
Grandy, DK
影响因子：
64.5
作者：
Mombaerts, P;Wang, F;Axel, R
通讯作者：
Axel, R
影响因子：
64.5
作者：
Malnic, B;Hirono, J;Buck, LB
通讯作者：
Buck, LB