Demographic, socio-environmental, and substance-related predictors of duration of untreated psychosis (DUP).
Demographic, socio-environmental, and substance-related predictors of duration of untreated psychosis (DUP).
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DOI：
10.1016/j.schres.2013.05.011
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发表时间：
2013-08
影响因子：
4.5
通讯作者：
Compton MT
中科院分区：
文献类型：
--
作者：
Broussard B;Kelley ME;Wan CR;Cristofaro SL;Crisafio A;Haggard PJ;Myers NL;Reed T;Compton MT
未经治疗的精神病（DUP）持续时间较长与早期和长期结局较差相关，并且是早期发现和干预工作的目标。由于缺乏对儿童和青少年压力源的研究（例如，虐待和邻里关系障碍）作为DUP的潜在预测因素，对病前物质使用作为DUP决定因素的研究有限，以及DUP与神经认知之间关联的不确定结果，我们进行了三组分析来解决这些问题。考虑到其作为DUP的疾病水平相关因素的既定作用，还考虑了精神病的发病模式。我们在180名主要是非洲裔美国人，低收入和社会弱势的首发精神病患者中严格评估了DUP和其他相关变量，这些患者在五个精神科住院。精神病的发病模式，以前的监禁，和儿童/青少年虐待的水平都是显着的独立预测DUP。关于病前物质使用，曾经使用过大麻和病前酒精使用量与DUP显著相关。七个神经认知领域中没有一个与DUP有适度或临床意义的相关性。DUP的这些和其他发现可能对早期发现和干预服务提供信息。例如，这种服务可能受益于特别推广到刑事司法环境和弱势社区，以及可能有童年/青少年虐待史并逐渐出现精神病症状的年轻人。
Longer duration of untreated psychosis (DUP) is associated with poorer early-course and long-term outcomes, and is a target of early detection and intervention efforts. Given the paucity of research on childhood and adolescent stressors (e.g., maltreatment and neighborhood disorder) as potential predictors of DUP, limited research on premorbid substance use as a determinant of DUP, and inconclusive findings on the association between DUP and neurocognition, we conducted three sets of analyses to address these issues. Mode of onset of psychosis was also considered, given its established role as an illness-level correlate of DUP. We rigorously assessed DUP and other pertinent variables in 180 predominantly African American, low-income, and socially disadvantaged first-episode psychosis patients hospitalized in five psychiatric units. Mode of onset of psychosis, prior incarceration, and the level of childhood/adolescent maltreatment were all significant independent predictors of DUP. Regarding premorbid substance use, having ever used cannabis and the amount of premorbid alcohol use were significantly associated with DUP. None of the seven neurocognitive domains were even modestly, or clinically meaningfully, associated with DUP. These and other findings on DUP may be informative for early detection and intervention services. For example, such services might benefit from special outreach to criminal justice settings and disadvantaged neighborhoods, and to young people likely to have a history of childhood/adolescent maltreatment and gradually developing psychotic symptoms.
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影响因子：
5.3
作者：
Compton, Michael T.;Gordon, Tynessa L.;Kaslow, Nadine J.
通讯作者：
Kaslow, Nadine J.
影响因子：
4.5
作者：
Malla, Ashok K.;Bodnar, Michael;Lepage, Martin
通讯作者：
Lepage, Martin
影响因子：
6.6
作者：
Brill, N.;Reichenberg, A.;Rabinowitz, J.
通讯作者：
Rabinowitz, J.
DOI：
10.1192/bjp.bp.108.049718
发表时间：
2008-09
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Barnes TR;Leeson VC;Mutsatsa SH;Watt HC;Hutton SB;Joyce EM
通讯作者：
Joyce EM
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W