Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.
Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.
复制标题
DOI：
10.3389/fmicb.2014.00690
复制
发表时间：
2014
影响因子：
5.2
通讯作者：
Reeves RK
中科院分区：
文献类型：
--
作者：
Manickam C;Reeves RK
丙型肝炎病毒（HCV）感染已成为全球公共卫生负担，每年造成数十亿美元的医疗费用。即使科学技术迅速进步，由于缺乏疫苗和负担得起的治疗方案，这种疾病仍然构成重大威胁。慢性病的保护和诱发因素的免疫相关性仍然是 HCV 疫苗和免疫治疗开发的主要障碍，至少部分原因是缺乏有形的感染动物模型。本综述讨论了目前可用的 HCV 疾病动物模型，主要关注新大陆灵长类动物的 GB 病毒 B (GBV-B) 感染，该模型概括了急性病毒清除和慢性病理性疾病的双重肝炎病毒表型。 HCV 和 GBV-B 在系统发育上也密切相关，新大陆灵长类动物免疫系统特征的进步已经导致该模型用于药物测试和疫苗试验。在此，我们讨论 GBV-B 感染模型的优点和注意事项，并讨论未来开发新型疫苗和免疫疗法的潜在途径。
Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines and affordable treatment options. The immune correlates of protection and predisposing factors toward chronicity remain major obstacles to development of HCV vaccines and immunotherapeutics due, at least in part, to lack of a tangible infection animal model. This review discusses the currently available animal models for HCV disease with a primary focus on GB virus B (GBV-B) infection of New World primates that recapitulates the dual Hepacivirus phenotypes of acute viral clearance and chronic pathologic disease. HCV and GBV-B are also closely phylogenetically related and advances in characterization of the immune systems of New World primates have already led to the use of this model for drug testing and vaccine trials. Herein, we discuss the benefits and caveats of the GBV-B infection model and discuss potential avenues for future development of novel vaccines and immunotherapies.
登录
查看更多内容
黑猩猩使用无干扰素抗病毒疗法治愈慢性丙型肝炎后的 T 细胞免疫和丙型肝炎病毒再感染。
影响因子：
13.5
作者：
Callendret, Benoit;Eccleston, Heather B.;Hall, Shelby;Satterfield, William;Capone, Stefania;Folgori, Antonella;Cortese, Riccardo;Nicosia, Alfredo;Walker, Christopher M.
通讯作者：
Walker, Christopher M.
影响因子：
3.7
作者：
Bukh, J;Apgar, CL;Yanagi, M
通讯作者：
Yanagi, M
影响因子：
12.7
作者：
Bukh, J;Apgar, CL;Purcell, RH
通讯作者：
Purcell, RH
影响因子：
13.5
作者：
ABE, K;INCHAUSPE, G;PRINCE, AM
通讯作者：
PRINCE, AM
影响因子：
5.4
作者：
Bassett, SE;Brasky, KM;Lanford, RE
通讯作者：
Lanford, RE