Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.
Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.
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清醒狗左心室收缩末期压力-容积关系对各种收缩状态的反应。
DOI：
10.1161/01.cir.78.3.736
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发表时间：
1988
期刊：
影响因子：
37.8
通讯作者：
Vinten-Johansen,J
中科院分区：
文献类型：
--
作者：
Little,WC;Cheng,CP;Peterson,T;Vinten-Johansen,J
我们评估了清醒犬左室收缩末期压力(PES)-容量(VES)关系在多种收缩状态下的线性和斜率。实验动物通过超声测量左心室内径来确定左心室容量，并用微型压力计测量左心室压力。在动物意识清醒的情况下，在器械安装后1-2周进行研究。递增注射多巴酚丁胺(0、2、4、6和8微克/公斤/分钟静脉注射)可增加收缩状态。维拉帕米(10 mg，i.v.)在自主神经封锁后给予。由双腔静脉阻断产生的PES-VES关系的44+/-11 mm Hg(平均值+/-SD)部分表现出轻微但一致的非线性，明显地表现为向容积轴的凹陷。这种在所有正性肌力状态下都存在的非线性并没有阻止PES-VES关系用直线来很好地近似(r=0.984+/-0.020，SEE=2.1+/-1.4 mm Hg)；此外，PES-VES线的斜率提供了收缩状态的敏感指标，随着多巴酚丁胺剂量的增加而递增，而对异搏定的反应递减。PES-VES关系的线性近似的体积轴截距比非线性二次拟合法的体积轴截距小2.9+/-3.3ml(p<0.05)。因此，线性的PES-VES关系，其斜率对多种变力状态敏感，是对清醒犬双腔闭塞所产生的PES-VES点范围内左心室的合理而有用的描述。然而，超出数据点范围的关系的线性外推可能不准确。
We assessed the linearity and slope of the left ventricular end-systolic pressure (PES)-volume (VES) relation over a wide range of contractile states in conscious dogs. The animals were instrumented to determine left ventricular volume from ultrasonic left ventricular internal dimensions and measure left ventricular pressure with a micromanometer. Studies were performed 1-2 weeks after instrumentation while the animals were conscious. Contractile state was increased by incremental infusion of dobutamine (0, 2, 4, 6, and 8 micrograms/kg/min i.v.) and decreased by verapamil (10 mg i.v.) given after autonomic blockade. The 44 +/- 11 mm Hg (mean +/- SD) portion of the PES-VES relation generated by bicaval occlusion demonstrated a slight but consistent nonlinearity, apparent as a concavity toward the volume axis. This nonlinearity, present at all inotropic states, did not prevent the PES-VES relation from being well approximated by a straight line (r = 0.984 +/- 0.020, SEE = 2.1 +/- 1.4 mm Hg); furthermore, the slope of the PES-VES line provided a sensitive index of contractile state, progressively increasing with incremental doses of dobutamine and decreasing in response to verapamil. The volume-axis intercept of the linear approximation of the PES-VES relation was 2.9 +/- 3.3 ml less (p less than 0.05) than the volume-axis intercept of the nonlinear quadratic fit. Thus, the linear PES-VES relation, whose slope is sensitive to a wide variety of inotropic states, is a reasonable and useful description of the left ventricle in the range of PES-VES points that can be produced by bicaval occlusion in the conscious dog. However, linear extrapolation of the relation beyond the range of data points may not be accurate.
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影响因子：
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影响因子：
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