Flavonoids against the SARS-CoV-2 induced inflammatory storm.
Flavonoids against the SARS-CoV-2 induced inflammatory storm.
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类黄酮抗SARS-CoV-2诱导的炎症风暴。
DOI：
10.1016/j.biopha.2021.111430
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kubatka P
中科院分区：
文献类型：
--
作者：
Liskova A;Samec M;Koklesova L;Samuel SM;Zhai K;Al-Ishaq RK;Abotaleb M;Nosal V;Kajo K;Ashrafizadeh M;Zarrabi A;Brockmueller A;Shakibaei M;Sabaka P;Mozos I;Ullrich D;Prosecky R;La Rocca G;Caprnda M;Büsselberg D;Rodrigo L;Kruzliak P;Kubatka P
COVID-19的疾病严重程度，特别是在老年人和合并症患者中，以高细胞因子血症为特征，这是一种与促炎细胞因子介质（细胞因子风暴）的不受控制和过度释放相关的过度免疫反应。黄酮类化合物是植物重要的次生代谢产物，由于其对烟碱的调节作用，长期以来一直被研究作为炎症性疾病的治疗干预措施。在这篇综述中，我们讨论了类黄酮在调节对COVID-19疾病至关重要的信号通路中的潜在作用，特别是与炎症和免疫相关的信号通路。类黄酮的免疫调节能力，通过调节炎症介质，抑制内皮细胞活化，NLRP 3炎性体，Toll样受体（TLR）或含溴结构域蛋白4（BRD 4），以及激活核因子红细胞衍生2相关因子2（Nrf 2），可能有利于调节SARS-CoV-2感染期间的细胞因子风暴。此外，黄酮类化合物抑制二肽基肽酶4（DPP 4）、中和3-糜蛋白酶样蛋白酶（3CLpro）或影响肠道微生物群以维持免疫应答的能力，以及血管紧张素转换酶2（ACE-2）的双重作用也可能潜在地应用于SARS-CoV-2诱导的过度炎症反应。基于先前证实的类黄酮在其他疾病中的作用，或基于新发表的与COVID-19相关的研究（生物信息学、分子对接），我们有理由假设类黄酮对COVID-19相关的炎症变化有积极作用。这篇综述强调了类黄酮在COVID-19管理中的效用的知识现状，并指出类黄酮对与SARS-CoV-2诱导的病理学中失调的炎症过程相关的信号通路的多种生物学效应。识别病原体，包括天然存在的物质，如类黄酮，是管理COVID-19的一种潜在方法。尽管尚未进行临床研究，但由于类黄酮具有广泛的生物活性，其对COVID-19的适用性可能是一种有希望的策略。
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out by the regulation of inflammatory mediators, the inhibition of endothelial activation, NLRP3 inflammasome, toll-like receptors (TLRs) or bromodomain containing protein 4 (BRD4), and the activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2), might be beneficial in regulating the cytokine storm during SARS-CoV-2 infection. Moreover, the ability of flavonoids to inhibit dipeptidyl peptidase 4 (DPP4), neutralize 3-chymotrypsin-like protease (3CLpro) or to affect gut microbiota to maintain immune response, and the dual action of angiotensin-converting enzyme 2 (ACE-2) may potentially also be applied to the exaggerated inflammatory responses induced by SARS-CoV-2. Based on the previously proven effects of flavonoids in other diseases or on the basis of newly published studies associated with COVID-19 (bioinformatics, molecular docking), it is reasonable to assume positive effects of flavonoids on inflammatory changes associated with COVID-19. This review highlights the current state of knowledge of the utility of flavonoids in the management of COVID-19 and also points to the multiple biological effects of flavonoids on signaling pathways associated with the inflammation processes that are deregulated in the pathology induced by SARS-CoV-2. The identification of agents, including naturally occurring substances such as flavonoids, represents great approach potentially utilizable in the management of COVID-19. Although not clinically investigated yet, the applicability of flavonoids against COVID-19 could be a promising strategy due to a broad spectrum of their biological activities.
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影响因子：
2.8
作者：
da Silva FMA;da Silva KPA;de Oliveira LPM;Costa EV;Koolen HH;Pinheiro MLB;de Souza AQL;de Souza ADL
通讯作者：
de Souza ADL
DOI：
10.1007/bf01965393
发表时间：
1982-01-01
期刊：
AGENTS AND ACTIONS
影响因子：
--
作者：
AGARWAL, OP
通讯作者：
AGARWAL, OP
影响因子：
5.9
作者：
Estruel-Amades, Sheila;Massot-Cladera, Malen;Camps-Bossacoma, Mariona
通讯作者：
Camps-Bossacoma, Mariona
影响因子：
3
作者：
Du, Yao;Han, Jibo;Ge, Weihong
通讯作者：
Ge, Weihong
DOI：
10.1016/j.ijbiomac.2020.07.235
发表时间：
2020-12-01
影响因子：
8.2
作者：
Abian, Olga;Ortega-Alarcon, David;Velazquez-Campoy, Adrian
通讯作者：
Velazquez-Campoy, Adrian