Altered Neurocognitive Functional Connectivity and Activation Patterns Underlie Psychopathology in Preadolescence.
Altered Neurocognitive Functional Connectivity and Activation Patterns Underlie Psychopathology in Preadolescence.
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DOI：
10.1016/j.bpsc.2020.09.007
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Mewton L
中科院分区：
文献类型：
--
作者：
Lees B;Squeglia LM;McTeague LM;Forbes MK;Krueger RF;Sunderland M;Baillie AJ;Koch F;Teesson M;Mewton L
神经认知缺陷在患有精神障碍的青少年中很常见，异常的大脑功能模式通常会跨越诊断界限。这项研究调查了精神病理学兴起的关键青春期前时期功能性神经回路与广泛的跨诊断精神病理学维度之间的关联。参与者是来自青少年大脑认知发展研究®的 9-10 岁儿童。一般精神病理学、外化、内化和思维障碍维度的因子得分是使用验证性因子分析 (n=11,721) 根据精神病理学高阶模型计算的，并作为解释变量输入线性混合模型，以检查与性别、种族/民族、父母教育和认知共变时情绪 N-back 任务 (n=6,146) 期间静息状态功能连接 (n=9,074) 和神经激活的关联功能。精神病理学的所有方面的共同特征是：背侧注意和压后颞叶网络内的连接性低下；额顶叶和腹侧注意网络之间以及背侧注意网络和杏仁核之间的超连接；以及尾部额中回的低活性。外化病理学与显着性和腹侧注意网络之间的过度连接以及扣带皮层和纹状体的过度激活有着独特的相关性。内化病理学的独特特征是默认模式和扣带盖网络之间的连接性低下。扣带-盖网络与壳核之间的连通性对于内化病理学而言特别较高，而对于思维障碍病理学而言则较低。这些发现提供了新的证据，表明广泛的精神病理学维度的特征是共同的和可分离的模式，特别是对于外化病理学、青春期前整个神经认知网络的功能连接和任务诱发的激活。
Neurocognitive deficits are common among youth with mental disorders and patterns of aberrant brain function generally cross diagnostic boundaries. This study investigated associations between functional neurocircuitry and broad transdiagnostic psychopathology dimensions in the critical preadolescent period when psychopathology is emerging. Participants were 9–10-year-olds from the Adolescent Brain Cognitive Development Study®. Factor scores of general psychopathology, externalizing, internalizing, and thought disorder dimensions were calculated from a higher-order model of psychopathology using confirmatory factor analysis (n=11,721) and entered as explanatory variables into linear mixed models to examine associations with resting state functional connectivity (n=9,074) and neural activation during the Emotional N-back task (n=6,146), when covarying for sex, race/ethnicity, parental education, and cognitive function. All dimensions of psychopathology were commonly characterized by: hypoconnectivity within the dorsal attention and retrosplenial-temporal networks; hyperconnectivity between the frontoparietal and ventral attention networks and between the dorsal attention network and amygdala; and hypoactivation of the caudal middle frontal gyrus. Externalizing pathology was uniquely associated with hyperconnectivity between the salience and ventral attention networks and hyperactivation of the cingulate and striatum. Internalizing pathology was uniquely characterized by hypoconnectivity between the default mode and cingulo-opercular networks. Connectivity between the cingulo-opercular network and putamen was uniquely higher for internalizing pathology and lower for thought disorder pathology. These findings provide novel evidence that broad psychopathology dimensions are characterized by common and dissociable patterns, particularly for externalizing pathology, of functional connectivity and task-evoked activation throughout neurocognitive networks in preadolescence.
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影响因子：
12.6
作者：
Conway, Christopher C.;Forbes, Miriam K.;Eaton, Nicholas R.
通讯作者：
Eaton, Nicholas R.
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
3.1
作者：
Kessler, Ronald C.;Petukhova, Maria;Sampson, Nancy A.;Zaslavsky, Alan M.;Wittchen, Hans-Ullrich
通讯作者：
Wittchen, Hans-Ullrich
影响因子：
6.9
作者：
Carragher, N.;Teesson, M.;Slade, T.
通讯作者：
Slade, T.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y