Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs).
Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs).
复制标题
环境刺激对骨髓衍生的间充质干细胞（BM-MSC）中的脂肪形成和成骨命运决定的相互影响。
DOI：
10.3390/cells12101400
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发表时间：
2023-05-16
期刊：
影响因子：
6
通讯作者：
Chen, Jiangang
中科院分区：
文献类型：
--
作者：
Xu, Xinyun;Zhao, Ling;Terry, Paul D.;Chen, Jiangang
骨髓间充质干细胞（BM-MSCs）可以分化为脂肪细胞和成骨细胞。各种外部刺激，包括环境污染物，重金属，饮食和物理因素，被证明会影响BM-MSCs向脂肪生成或骨生成的命运决定。骨生成和脂肪生成的平衡对于维持骨稳态是至关重要的，并且BM-MSC谱系定型的中断与人类健康问题相关，例如骨折、骨质疏松症、骨质减少和骨坏死。本文就外界刺激如何改变骨髓间充质干细胞向成脂或成骨方向的命运作一综述。未来的研究需要了解这些外部刺激对骨健康的影响，并阐明BM-MSCs分化的潜在机制。这些知识将为预防骨相关疾病和开发治疗方法以治疗与各种病理条件相关的骨疾病的努力提供信息。
Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into adipocytes and osteoblasts. Various external stimuli, including environmental contaminants, heavy metals, dietary, and physical factors, are shown to influence the fate decision of BM-MSCs toward adipogenesis or osteogenesis. The balance of osteogenesis and adipogenesis is critical for the maintenance of bone homeostasis, and the interruption of BM-MSCs lineage commitment is associated with human health issues, such as fracture, osteoporosis, osteopenia, and osteonecrosis. This review focuses on how external stimuli shift the fate of BM-MSCs towards adipogenesis or osteogenesis. Future studies are needed to understand the impact of these external stimuli on bone health and elucidate the underlying mechanisms of BM-MSCs differentiation. This knowledge will inform efforts to prevent bone-related diseases and develop therapeutic approaches to treat bone disorders associated with various pathological conditions.
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影响因子：
12.4
作者：
Chen Q;Shou P;Zheng C;Jiang M;Cao G;Yang Q;Cao J;Xie N;Velletri T;Zhang X;Xu C;Zhang L;Yang H;Hou J;Wang Y;Shi Y
通讯作者：
Shi Y
影响因子：
4.1
作者：
Ali, Dalia;Chen, Li;Alfayez, Musaad
通讯作者：
Alfayez, Musaad
影响因子：
4.1
作者：
Baker, Amelia H.;Watt, James;Schlezinger, Jennifer J.
通讯作者：
Schlezinger, Jennifer J.
影响因子：
8.5
作者：
Dai, Z. Q.;Wang, R.;Li, Y. H.
通讯作者：
Li, Y. H.
影响因子：
29
作者：
Cawthorn WP;Scheller EL;Learman BS;Parlee SD;Simon BR;Mori H;Ning X;Bree AJ;Schell B;Broome DT;Soliman SS;DelProposto JL;Lumeng CN;Mitra A;Pandit SV;Gallagher KA;Miller JD;Krishnan V;Hui SK;Bredella MA;Fazeli PK;Klibanski A;Horowitz MC;Rosen CJ;MacDougald OA
通讯作者：
MacDougald OA