Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
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DOI：
10.1016/j.cmet.2014.06.003
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发表时间：
2014-08-05
期刊：
影响因子：
29
通讯作者：
MacDougald OA
中科院分区：
文献类型：
--
作者：
Cawthorn WP;Scheller EL;Learman BS;Parlee SD;Simon BR;Mori H;Ning X;Bree AJ;Schell B;Broome DT;Soliman SS;DelProposto JL;Lumeng CN;Mitra A;Pandit SV;Gallagher KA;Miller JD;Krishnan V;Hui SK;Bredella MA;Fazeli PK;Klibanski A;Horowitz MC;Rosen CJ;MacDougald OA
脂肪细胞衍生的激素脂联素可促进代谢和心血管健康。在热量限制 (CR) 等瘦身状态下，循环脂联素会增加，但这种悖论的原因仍不清楚。与白色脂肪组织 (WAT) 不同，骨髓脂肪组织 (MAT) 在 CR 期间增加，并且 MAT 和血清脂联素在许多其他临床状况下都会增加。因此，我们研究了 MAT 是否有助于循环脂联素。我们发现 MAT 的脂联素分泌量高于 WAT。值得注意的是，尽管 WAT 中的脂联素表达没有改变，但对小鼠 MAT 形成的特异性抑制会导致 CR 期间循环脂联素减少。抑制 MAT 形成还会改变骨骼肌对 CR 的适应，表明 MAT 发挥全身作用。最后，我们揭示了人类癌症治疗期间 MAT 和血清脂联素都会增加。这些观察结果表明，MAT 是一种内分泌器官，在 CR 期间以及可能在其他不良状态下对血清脂联素的增加有显着贡献。
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated if MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than from WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR, despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR, and perhaps in other adverse states.
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影响因子：
9.8
作者：
Behre, Carl Johan;Gummesson, Anders;Carlsson, Lena M. S.
通讯作者：
Carlsson, Lena M. S.
DOI：
10.1152/ajpendo.00172.2004
发表时间：
2004-11-01
影响因子：
5.1
作者：
Gonzalez, AA;Kumar, R;Saupe, KW
通讯作者：
Saupe, KW
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3.4
作者：
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Morikawa, H
影响因子：
82.9
作者：
Maeda, N;Shimomura, I;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
6.9
作者：
Li, Xingsheng;Cope, Mark B.;Johnson, Maria S.;Smith, Daniel L., Jr.;Nagy, Tim R.
通讯作者：
Nagy, Tim R.