Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study.
Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study.
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评估海洛因依赖者中线索诱发的大脑反应与戒断持续时间的关系：一项与事件相关的功能磁共振成像研究
DOI：
10.1371/journal.pone.0062911
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Li Q;Wang Y;Zhang Y;Li W;Zhu J;Zheng Y;Chen J;Zhao L;Zhou Z;Liu Y;Wang W;Tian J
海洛因相关线索诱发的脑活动可能在海洛因依赖的维持过程中起一定作用。无论是强化还是加工偏差都构成了海洛因成瘾的永久特征，这一问题仍有待解决。我们使用事件相关的功能磁共振成像范式来测量海洛因依赖患者在短期和长期戒断时对海洛因线索相关图片与中性图片作为对照条件的大脑激活。提示暴露后，短期戒断者的自我报告渴求评分显著增加（t = 3.000，P = 0.008），而长期戒断者的自我报告渴求评分无显著增加（t = 1.510，P = 0.149）。 两组在线索诱发的渴求变化上差异无统计学意义（t = 1.193，P = 0.850）。 长期戒断组与短期戒断组比较，双侧前扣带回、左侧内侧前额叶、尾状核、枕中回、顶下小叶和右侧楔前叶的脑激活显著降低。海洛因依赖者戒断时间与左内侧前额叶和左顶下小叶的脑激活呈负相关。这些研究结果表明，长期禁欲可能是有用的海洛因依赖患者，以减少他们的显着价值的海洛因相关线索，并可能降低复发的脆弱性在一定程度上。
The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved. We used an event-related fMRI paradigm to measure brain activation in response to heroin cue-related pictures versus neutral pictures as the control condition in heroin-dependent patients undergoing short-term and long-term abstinence. The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149). However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850). Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus. Among all of the heroin dependent patients, the abstinence duration was negatively correlated with brain activation in the left medial prefrontal cortex and left inferior parietal lobule. These findings suggest that long-term abstinence may be useful for heroin-dependent patients to diminish their saliency value of heroin-related cues and possibly lower the relapse vulnerability to some extent.
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影响因子：
17.7
作者：
Langleben, Daniel D.;Ruparel, Kosha;Childress, Anna R.
通讯作者：
Childress, Anna R.
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
7.6
作者：
Franklin, Teresa R.;wang, Ze;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
DOI：
10.1073/pnas.0903863106
发表时间：
2009-08-04
影响因子：
11.1
作者：
Filbey, Francesca M.;Schacht, Joseph P.;Hutchison, Kent E.
通讯作者：
Hutchison, Kent E.
影响因子：
2.5
作者：
Fu, Li-ping;Bi, Guo-hua;Yang, Zheng
通讯作者：
Yang, Zheng