Cohort profile: The Chikwawa lung health cohort; a population-based observational non-communicable respiratory disease study of adults in Malawi.
Cohort profile: The Chikwawa lung health cohort; a population-based observational non-communicable respiratory disease study of adults in Malawi.
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DOI：
10.1371/journal.pone.0242226
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
IMPALA Consortium
中科院分区：
文献类型：
--
作者：
Njoroge MW;Rylance S;Nightingale R;Gordon S;Mortimer K;Burney P;Rylance J;Obasi A;Niessen L;Devereux G;IMPALA Consortium
这篇文章的目的是提供一个详细的描述Chikwawa肺健康队列，这是建立在农村马拉维前瞻性地确定肺部疾病的患病率和原因之间的一般人口的成年人生活在撒哈拉以南非洲地区的低收入农村环境。2014年，共有1481名参与者被随机识别并招募用于基线研究。我们收集了有关人口统计学、社会经济状况、呼吸道症状和潜在相关暴露（如吸烟、家用燃料、环境暴露、职业史/暴露、饮食摄入、医疗保健利用、成本（药物、门诊和住院）和生产力损失）的数据。进行肺活量测定以评估肺功能。基线时，56.9%的参与者为女性，平均年龄为43.8（SD：17.8），平均体重指数（BMI）为21.6 Kg/m2（标准差：3.46）该队列报告了慢性呼吸道症状的患病率（13.6%，95%置信区间[CI]，11.9-15.4），肺功能测定阻塞（8.7%，95% CI，7.0-10.7）和肺活量限制（34.8%，95% CI，31.7-38.0）。此外，据报告，1秒用力呼气量[FEV 1]每年下降30.9 mL/年（95% CI：21.6 - 40.1），用力肺活量[FVC]每年下降38.3 mL/年（95% CI：28.5 - 48.1）。正在进行的随访阶段将确定通过肺量测定法测量的肺功能年下降率以及气流阻塞和限制的发展，并将其与发病率、死亡率和气流阻塞和限制的经济成本相关联。将根据马拉维队列和国家人口数据的经验数据，开发基于人口的数学模型，以评估干预措施和方案对解决马拉维肺部负担的影响。本随访研究于2019年开始。
The aim of this article is to provide a detailed description of the Chikwawa lung health cohort which was established in rural Malawi to prospectively determine the prevalence and causes of lung disease amongst the general population of adults living in a low-income rural setting in Sub-Saharan Africa. A total of 1481 participants were randomly identified and recruited in 2014 for the baseline study. We collected data on demographic, socio-economic status, respiratory symptoms and potentially relevant exposures such as smoking, household fuels, environmental exposures, occupational history/exposures, dietary intake, healthcare utilization, cost (medication, outpatient visits and inpatient admissions) and productivity losses. Spirometry was performed to assess lung function. At baseline, 56.9% of the participants were female, mean age was 43.8 (SD:17.8) and mean body mass index (BMI) was 21.6 Kg/m2 (SD: 3.46) The cohort has reported the prevalence of chronic respiratory symptoms (13.6%, 95% confidence interval [CI], 11.9–15.4), spirometric obstruction (8.7%, 95% CI, 7.0–10.7), and spirometric restriction (34.8%, 95% CI, 31.7–38.0). Additionally, an annual decline in forced expiratory volume in one second [FEV1] of 30.9mL/year (95% CI: 21.6 to 40.1) and forced vital capacity [FVC] by 38.3 mL/year (95% CI: 28.5 to 48.1) has been reported. The ongoing phases of follow-up will determine the annual rate of decline in lung function as measured through spirometry and the development of airflow obstruction and restriction, and relate these to morbidity, mortality and economic cost of airflow obstruction and restriction. Population-based mathematical models will be developed driven by the empirical data from the cohort and national population data for Malawi to assess the effects of interventions and programmes to address the lung burden in Malawi. The present follow-up study started in 2019.
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DOI：
10.1164/rccm.200811-1757st
发表时间：
2010-09-01
影响因子：
24.7
作者：
Eisner, Mark D.;Anthonisen, Nicholas;Balmes, John R.
通讯作者：
Balmes, John R.
影响因子：
7.7
作者：
Adab, P.;Fitzmaurice, D. A.;Jordan, R. E.
通讯作者：
Jordan, R. E.
DOI：
10.1183/09031936.00002711
发表时间：
2012-06
期刊：
The European respiratory journal
影响因子：
--
作者：
Hooper R;Burney P;Vollmer WM;McBurnie MA;Gislason T;Tan WC;Jithoo A;Kocabas A;Welte T;Buist AS
通讯作者：
Buist AS
DOI：
10.1183/09031936.00142414
发表时间：
2015-05
期刊：
The European respiratory journal
影响因子：
--
作者：
Burney PG;Patel J;Newson R;Minelli C;Naghavi M
通讯作者：
Naghavi M
影响因子：
3.7
作者：
Banda HT;Thomson R;Mortimer K;Bello GAF;Mbera GB;Malmborg R;Faragher B;Squire SB
通讯作者：
Squire SB