Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex
Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex
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额叶皮层身体唤醒的决策与内感受表征之间的相互作用
DOI：
10.1101/2021.02.04.429750
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发表时间：
2021
影响因子：
11.1
通讯作者：
P. Rudebeck
中科院分区：
文献类型：
--
作者：
A. Fujimoto;E. Murray;P. Rudebeck
意义身体唤醒状态如何影响决策一直是心理学的中心问题，但其神经机制尚不清楚。我们记录了心率(HR)，这是一种身体唤醒的指标，同时监测做出奖励引导决策的猕猴眼眶前额叶皮质(OFC)和背侧前扣带回皮质(DACC)的神经活动。在完整的猕猴中，较高的心率与较短的反应时间相关。同时，OFC和dACC内一组神经元的活动选择性地编码HR。杏仁核损伤后，HR普遍增加，现在HR与反应时的关系发生了改变。在神经水平上，dACC的编码平衡向信号HR转移，这表明身体唤醒通过一种特定的机制影响决策。决策和唤醒的表现是紧密相连的。经典的行为研究表明，身体唤醒太少或太多都不利于决策，这表明身体唤醒与表现之间存在倒U型关系。这些过程是如何在单个神经元水平上相互作用的，以及涉及的神经回路尚不清楚。在这里，我们记录了猕猴在做出奖励引导决策时的眼眶前额叶皮质(OFC)和背侧前扣带回皮质(DACC)的神经活动。心率(HR)也被记录下来，并作为身体唤醒的指标。在受试者接受双侧杏仁核兴奋性毒性损伤之前和之后都进行了记录。在完整的猴子中，较高的心率促进了反应时间(RTS)。同时，OFC和dACC中的一组神经元选择性地编码HR的逐个试验的变化，而不依赖于奖励值。杏仁核损毁后，HR增加，HR与RTS的关系发生改变。在这种变化的同时，编码HR的dACC神经元的比例增加。应用群体编码分析，我们表明，在双侧杏仁核损伤后，dACC中的编码平衡在做出选择的时候从发出奖赏价值或选择方向的信号向HR编码倾斜。综上所述，目前的结果提供了对身体唤醒和决策是如何在额叶皮质发出信号的洞察。
Significance How bodily arousal states influence decision-making has been a central question in psychology, but the neural mechanisms are unclear. We recorded heart rate (HR), a measure of bodily arousal, while simultaneously monitoring neural activity in orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaques making reward-guided decisions. In intact macaques, higher HR was associated with shorter reaction times. Concurrently, the activity of a set of neurons in OFC and dACC selectively encoded HR. Following amygdala lesions, HR generally increased, and now the relationship between HR and reaction times was altered. At the neural level, the balance of encoding in dACC shifted toward signaling HR, suggesting a specific mechanism through which bodily arousal influences decision-making. Decision-making and representations of arousal are intimately linked. Behavioral investigations have classically shown that either too little or too much bodily arousal is detrimental to decision-making, indicating that there is an inverted “U” relationship between bodily arousal and performance. How these processes interact at the level of single neurons as well as the neural circuits involved are unclear. Here we recorded neural activity from orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaque monkeys while they made reward-guided decisions. Heart rate (HR) was also recorded and used as a proxy for bodily arousal. Recordings were made both before and after subjects received excitotoxic lesions of the bilateral amygdala. In intact monkeys, higher HR facilitated reaction times (RTs). Concurrently, a set of neurons in OFC and dACC selectively encoded trial-by-trial variations in HR independent of reward value. After amygdala lesions, HR increased, and the relationship between HR and RTs was altered. Concurrent with this change, there was an increase in the proportion of dACC neurons encoding HR. Applying a population-coding analysis, we show that after bilateral amygdala lesions, the balance of encoding in dACC is skewed away from signaling either reward value or choice direction toward HR coding around the time that choices are made. Taken together, the present results provide insight into how bodily arousal and decision-making are signaled in frontal cortex.
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DOI：
10.1176/appi.ajp.2016.15111410
发表时间：
2017-02-01
期刊：
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影响因子：
--
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