Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance.
Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance.
复制标题
被动回避期间患有普遍焦虑症的个体的预测错误表示。
DOI：
10.1176/appi.ajp.2016.15111410
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Blair KS
中科院分区：
文献类型：
--
作者：
White SF;Geraci M;Lewis E;Leshin J;Teng C;Averbeck B;Meffert H;Ernst M;Blair JR;Grillon C;Blair KS
在广泛性焦虑障碍中已经报道了基于强化的决策缺陷。然而，这些缺陷的病理生理学在很大程度上是未知的，现有的研究主要是针对年轻人，而支持决策的核心功能过程的完整性仍然不确定。特别是，目前尚不清楚在广泛性焦虑障碍中，强化预测误差（PE：收到的和期望的强化之间的差异）的表征是否被破坏。目前的研究针对的是患有这种疾病的成年人。46名未接受药物治疗的广泛性焦虑症患者和32名智商、性别和年龄匹配的健康对照组，在接受功能性MRI检查的同时完成了被动回避任务。行为上，患有广泛性焦虑症的个体表现出基于强化的决策受损。成像结果显示，在反馈过程中，与健康对照组相比，广泛性焦虑障碍患者的PE与腹内侧前额叶皮层、腹侧纹状体和其他与决策有关的结构的活动之间的相关性降低。此外，与健康参与者相比，患有广泛性焦虑障碍的个体表现出惩罚（而非奖励）、PEs和双侧慢状核/壳核活动之间的相关性降低。这是第一个确定广泛性焦虑障碍患者决策过程中的计算障碍的研究。PE信号在患有这种疾病的个体中明显中断，这可能是广泛性焦虑症患者中观察到的决策缺陷的基础。
Deficits in reinforcement-based decision-making have been reported in Generalized Anxiety Disorder. However, the pathophysiology of these deficits is largely unknown, extant studies have mainly examined youth and the integrity of core functional processes underpinning decision-making remain undetermined. In particular, it is unclear whether the representation of reinforcement prediction error (PE: the difference between received and expected reinforcement) is disrupted in Generalized Anxiety Disorder. The current study addresses these issues in adults with the disorder. Forty-six un-medicated individuals with Generalized Anxiety Disorder and 32 healthy controls group-matched on IQ, gender and age, completed a passive avoidance task while undergoing functional MRI. Behaviorally, individuals with Generalized Anxiety Disorder showed impaired reinforcement-based decision-making. Imaging results revealed that during feedback, individuals with Generalized Anxiety Disorder relative to healthy controls showed a reduced correlation between PE and activity within ventromedial prefrontal cortex, ventral striatum and other structures implicated in decision-making. In addition, individuals with Generalized Anxiety Disorder relative to healthy participants showed a reduced correlation between punishment, but not reward, PEs and activity within bilateral lentiform nucleus/putamen. This is the first study to identify computational impairments during decision-making in Generalized Anxiety Disorder. PE signaling is significantly disrupted in individuals with the disorder and may underpin the decision-making deficits observed in patients with GAD.
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影响因子：
7.4
作者：
Galvan, Adriana;Peris, Tara S.
通讯作者：
Peris, Tara S.
影响因子：
3.7
作者：
Luhmann, Christian C.;Ishida, Kanako;Hajcak, Greg
通讯作者：
Hajcak, Greg
DOI：
10.1111/j.1749-6632.2011.06290.x
发表时间：
2011-01-01
期刊：
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR
影响因子：
--
作者：
O'Doherty, John P.
通讯作者：
O'Doherty, John P.
DOI：
10.1176/appi.ajp.2012.12060840
发表时间：
2013-03
期刊：
The American journal of psychiatry
影响因子：
--
作者：
White SF;Pope K;Sinclair S;Fowler KA;Brislin SJ;Williams WC;Pine DS;Blair RJ
通讯作者：
Blair RJ
影响因子：
5.3
作者：
Engelmann, Jan B.;Meyer, Friederike;Ruff, Christian C.
通讯作者：
Ruff, Christian C.