Nutraceuticals in colorectal cancer: A mechanistic approach.
Nutraceuticals in colorectal cancer: A mechanistic approach.
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DOI：
10.1016/j.ejphar.2018.06.027
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发表时间：
2018-08-15
影响因子：
5
通讯作者：
Bishehsari F
中科院分区：
文献类型：
--
作者：
Rossi M;Mirbagheri SEYEDS;Keshavarzian A;Bishehsari F
结直肠癌（CRC）是世界上诊断率最高的癌症之一。尽管筛查、手术和肿瘤学已经取得了很大的进步，但CRC仍然是癌症死亡的主要原因之一，男性和女性每年死亡人数均为70万。工业化带来的环境和生活方式因素，如饮食改变，缺乏体力活动，酒精消费增加和昼夜节律紊乱，极大地影响了CRC的负担。这些因素至少部分地通过病理改变结肠环境（包括肠道微生物群的组成，称为生态失调）来增加CRC风险。结肠生态失调可促进促癌免疫信号级联，导致促肿瘤性炎症、致癌物产生和易感宿主中改变的细胞应答，从而导致CRC的发生和/或进展。营养药物如益生元分子和益生菌菌种可以帮助维持肠道微生物稳态，从而减轻这种病理过程。因此，益生元和益生菌可以通过促进抗癌、抗炎免疫、维持肠上皮屏障、促凋亡机制和致癌物灭活来阻碍生态失调的影响。除了其在预防CRC方面的意义外，由于受影响的机制，营养品被发现作为免疫检查点抑制剂治疗CRC的潜在替代品。在这篇综述中，我们提供了益生元和益生菌在预防和治疗CRC的潜在影响的概述。
Colorectal cancer (CRC) is one of the most diagnosed cancers in the world. Even though screening, surgery and oncology have greatly advanced, CRC is still one of the leading causes of cancer deaths, with 700,000 annual mortalities in both men and women. Environmental and lifestyle factors brought up by industrialization, such as an altered diet, lack of physical activity, increase in alcohol consumption, and circadian disruption, have greatly affected the burden of CRC. These factors increase the CRC risk, at least partly, by pathologically altering the colonic environment, including composition of the gut microbiota, referred to as dysbiosis. Colonic dysbiosis can promote pro-carcinogenic immune signaling cascades, leading to pro-tumorigenic inflammation, carcinogen production, and altered cellular responses in susceptible host resulting to development and/or progression of CRC. Nutraceuticals such as prebiotic molecules and probiotic bacterial species can help maintain intestinal microbial homeostasis and thus mitigate this pathological processes. Therefore, prebiotics and probiotics can hinder the effects of dysbiosis by encouraging anti-carcinogenic, anti-inflammatory immunity, the maintenance of the intestinal epithelial barrier, pro-apoptotic mechanisms, and carcinogen inactivation. In addition to its implications in preventing CRC, because of the mechanisms affected, nutraceuticals are being discovered as potential adjuncts to immune checkpoint inhibitors in the treatment of CRC. In this review, we provide an overview of the potential implications of prebiotics and probiotics in the prevention and treatment of CRC.
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gnotobiotic小鼠模型表明，饮食纤维以微生物群和丁酸酯依赖性方式预防结肠直肠肿瘤发生。
影响因子：
28.2
作者：
Donohoe DR;Holley D;Collins LB;Montgomery SA;Whitmore AC;Hillhouse A;Curry KP;Renner SW;Greenwalt A;Ryan EP;Godfrey V;Heise MT;Threadgill DS;Han A;Swenberg JA;Threadgill DW;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
4.3
作者：
Bishehsari, Faraz;Mahdavinia, Mahboobeh;Mariani-Costantini, Renato
通讯作者：
Mariani-Costantini, Renato
光/暗转变促进酒精诱导的结肠癌发生：肠道炎症环境和微生物群的可能作用。
影响因子：
5.6
作者：
Bishehsari F;Saadalla A;Khazaie K;Engen PA;Voigt RM;Shetuni BB;Forsyth C;Shaikh M;Vitaterna MH;Turek F;Keshavarzian A
通讯作者：
Keshavarzian A
影响因子：
3.1
作者：
Dik VK;van Oijen MG;Smeets HM;Siersema PD
通讯作者：
Siersema PD