Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
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DOI：
10.1371/journal.pone.0192609
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Tobe K
中科院分区：
文献类型：
--
作者：
Iwata M;Hara K;Kamura Y;Honoki H;Fujisaka S;Ishiki M;Usui I;Yagi K;Fukushima Y;Takano A;Kato H;Murakami S;Higuchi K;Kobashi C;Fukuda K;Koshimizu Y;Tobe K
在三种脂联素亚型中，高相对分子质量(HMW)的脂联素(HMW)与总脂联素(TA)的比值较低是导致胰岛素抵抗和2型糖尿病(T2D)的主要原因。然而，其他脂联素亚型，如中分子量(MMW)和低分子量(LMW)亚型的水平，以及它们与TA变化的相对比率在T2D患者中是如何变化的还没有确定。因此，我们研究了这些脂联素相关参数与T2D的关系。我们从先前研究的参与者中随机选择了394名T2D受试者和374名对照组(第一组)，研究了脂联素相关参数与糖尿病之间的关系。这些参数与第二组的HOMA-IR之间的关系也被检查，第二组包括在排除接受糖尿病药物治疗的受试者后留在第一组的受试者。在调整混杂因素后，糖尿病组各脂联素亚型水平及HMW/TA比值均显著低于对照组(P均<0.01)。反之，LMW/TA比值在糖尿病患者中显著升高(P<；0.01)，且与T2D呈正相关(优势比=8.64，P<；0.01)。在第二组中，HMW/TA比值与HOMA-IR呈负相关，而LMW/TA比值与HOMA-IR呈正相关(β=0.89，SE=0.24，P<；0.001)，与T2D的相关性相似。MMW/TA比值与T2D或HOMA-IR无关。目前的研究表明，与所有脂联素亚型水平和HMW/TA比值的降低不同，LMW/TA比值的增加与T2D有关，其与胰岛素抵抗有关。
Among the three adiponectin isoforms, a lower ratio of high molecular weight (HMW) adiponectin to total adiponectin (TA) is well known to cause insulin resistance and type 2 diabetes (T2D). However, how the levels of other adiponectin isoforms, such as the middle molecular weight (MMW) and low molecular weight (LMW) isoforms, and their relative ratio to TA change in T2D subjects has not been determined. Therefore, we investigated the association of these adiponectin-related parameters with T2D. We examined the associations between adiponectin-related parameters and diabetes in a group of 394 T2D subjects and 374 controls (1st group) randomly selected from among the participants in our previous study. The associations between these parameters and the HOMA-IR in a 2nd group, consisting of the subjects remaining in the 1st group after the exclusion of subjects receiving diabetic medication, were also examined. In the 1st group, after adjusting for confounding factor, the levels of all the adiponectin isoforms and the HMW/TA ratio were significantly lower among the diabetic subjects than among the controls (all P values < 0.01). On the contrary, the LMW/TA ratio was significantly higher among the diabetic subjects (P < 0.01) and was positively associated with T2D (odds ratio = 8.64, P < 0.01). In the 2nd group, the HMW/TA ratio was inversely associated with the HOMA-IR; however, the LMW/TA ratio was positively associated with the HOMA-IR (β for LMW/TA ratio = 0.89, SE = 0.24, P < 0.001), similar to the association with T2D. The MMW/TA ratio was not associated with T2D or the HOMA-IR. The current investigation demonstrated that, unlike the reduction in the levels of all the adiponectin isoforms and the HMW/TA ratio, an increased LMW/TA ratio was associated with T2D through its relation to insulin resistance.
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影响因子：
3.7
作者：
Kamura Y;Iwata M;Maeda S;Shinmura S;Koshimizu Y;Honoki H;Fukuda K;Ishiki M;Usui I;Fukushima Y;Takano A;Kato H;Murakami S;Higuchi K;Kobashi C;Tobe K
通讯作者：
Tobe K
影响因子：
16.2
作者：
Iwata M;Maeda S;Kamura Y;Takano A;Kato H;Murakami S;Higuchi K;Takahashi A;Fujita H;Hara K;Kadowaki T;Tobe K
通讯作者：
Tobe K
影响因子：
4.8
作者：
Crispim, Felipe;Vendramini, Marcio F.;Moises, Regina S.
通讯作者：
Moises, Regina S.
影响因子：
3.5
作者：
Graessler, Juergen;Gruber, Matthias;Fischer, Sabine
通讯作者：
Fischer, Sabine
影响因子：
5.1
作者：
Iwase, Masanori;Iino, Kenzo;Iida, Mitsuo
通讯作者：
Iida, Mitsuo