Small fiber polyneuropathy as a potential therapeutic target in interstitial cystitis/bladder pain syndrome.

Small fiber polyneuropathy as a potential therapeutic target in interstitial cystitis/bladder pain syndrome.
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DOI:
10.1007/s00192-019-04011-x
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发表时间:
2019-11
影响因子:
1.8
通讯作者:
Walker SJ
Walker SJ
中科院分区:
医学3区
文献类型:
--
作者:
Matthews CA;Deveshwar SP;Evans RJ;Badlani G;Walker SJ

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间质性膀胱炎/膀胱疼痛综合征(IC/BPS)和纤维肌痛(FM)是转诊至泌尿科诊所接受二级和三级治疗选择的患者中常见的合并医学诊断。大量文献表明,许多纤维肌痛患者患有小纤维多发性神经病(SVPN),可以通过皮肤穿刺活检和免疫染色测量神经密度来证实。SVPN的这一发现为纤维肌痛提供了一个治疗靶点,在本文中,我们假设并提供了这样一个想法的基本原理,即这种相同的现象(SVPN)可以解释某些IC/BPS患者的广泛疼痛,同样也为这些患者提供了一个治疗靶点。这篇假设论文提出了评价间质性膀胱炎/膀胱疼痛综合征患者的小纤维多发性神经病作为广泛疼痛的潜在治疗靶点的基本原理。
Interstitial cystitis/bladder pain syndrome (IC/BPS) and fibromyalgia (FM) are frequently co-occurring medical diagnoses in patients referred to the urology clinic for secondary and tertiary treatment options. Abundant literature has shown that many patients with fibromyalgia have small fiber polyneuropathy (SFPN) that can be confirmed via skin punch biopsy and immunological staining to measure nerve density. This finding of SFPN provides a therapeutic target for fibromyalgia and in this article we hypothesize and provide rationale for the idea that this same phenomenon (SFPN) may explain, in some IC/BPS patients, the finding of widespread pain and likewise provide a therapeutic target for these patients. This hypothesis paper presents a rationale for evaluating small fiber polyneuropathy in interstitial cystitis/bladder pain syndrome patients as a potential therapeutic target for wide-spread pain.
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