Co-morbidities of interstitial cystitis.
Co-morbidities of interstitial cystitis.
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DOI：
10.3389/fnins.2012.00114
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发表时间：
2012
影响因子：
4.3
通讯作者：
Chelimsky T
中科院分区：
文献类型：
--
作者：
Chelimsky G;Heller E;Buffington CA;Rackley R;Zhang D;Chelimsky T
简介：本研究旨在估计间质性膀胱炎/膀胱疼痛综合征（IC/BPS）伴全身功能障碍相关共病（如肠易激综合征（IBS）和纤维肌痛（FM））的患者比例。材料与方法：包括两组IC/BPS受试者：（1）医生诊断的IC/BPS患者和（2）基于问卷（ODYSA）符合NIDDK IC/PBS标准的受试者。将这些组与年龄和社会经济地位相匹配的健康对照组进行比较。所需NIDDK标准：伴随膀胱充盈的疼痛，随着排空而改善，由于不适或疼痛引起的尿急，多尿>11次/24小时，以及排尿>2次/夜。ODYSA仪器评估与一系列疾病有关的症状，包括慢性疲劳、直立不耐受、晕厥、IBS、消化不良、周期性呕吐综合征、头痛和偏头痛、睡眠、雷诺综合征和慢性疼痛。结果如下：26名受试者（平均年龄47 ± 16岁，92%为女性）被诊断为IC/BPS，58名受试者根据NIDDK标准有IC/BPS症状（平均年龄40 ± 17岁，79%为女性），48名为健康对照（平均年龄31 ± 14岁，平均年龄77%）。IC/BPS组的共病主诉包括提示IBS和消化不良的胃肠道症状、睡眠异常伴延迟入睡、早晨感觉精神不振、需要前醒来、打鼾、重度慢性疲劳和慢性全身性疼痛、偏头痛和晕厥。讨论：IC/BPS患者伴有中枢和自主神经系统疾病。我们的研究结果反映了其他人关于IBS，FM，慢性疼痛和偏头痛的症状。在IC/BPS组中发现的晕厥和功能性消化不良的高发生率值得进一步研究，以确定IC/BPS是否是影响膀胱外多个器官的中枢、自主神经和感觉处理的弥漫性疾病的一部分。
Introduction: This study aimed to estimate the proportion of patients with interstitial cystitis/painful bladder syndrome (IC/BPS) with systemic dysfunction associated co-morbidities such as irritable bowel syndrome (IBS) and fibromyalgia (FM). Materials and Methods: Two groups of subjects with IC/BPS were included: (1) physician diagnosed patients with IC/BPS and (2) subjects meeting NIDDK IC/PBS criteria based on a questionnaire (ODYSA). These groups were compared to healthy controls matched for age and socio-economic status. NIDDK criteria required: pain with bladder filling that improves with emptying, urinary urgency due to discomfort or pain, polyuria >11 times/24 h, and nocturia >2 times/night. The ODYSA instrument evaluates symptoms pertaining to a range of disorders including chronic fatigue, orthostatic intolerance, syncope, IBS, dyspepsia, cyclic vomiting syndrome, headaches and migraines, sleep, Raynaud’s syndrome, and chronic aches and pains. Results: IC/BPS was diagnosed in 26 subjects (mean age 47 ± 16 years, 92% females), 58 had symptoms of IC/BPS by NIDDK criteria (mean age 40 ± 17 years, 79% females) and 48 were healthy controls (mean age 31 ± 14 years, mean age 77%). Co-morbid complaints in the IC/BPS groups included gastrointestinal symptoms suggestive of IBS and dyspepsia, sleep abnormalities with delayed onset of sleep, feeling poorly refreshed in the morning, waking up before needed, snoring, severe chronic fatigue and chronic generalized pain, migraines, and syncope. Discussion: Patients with IC/BPS had co-morbid central and autonomic nervous system disorders. Our findings mirror those of others in regard to IBS, symptoms suggestive of FM, chronic pain, and migraine. High rates of syncope and functional dyspepsia found in the IC/BPS groups merit further study to determine if IC/BPS is part of a diffuse disorder of central, autonomic, and sensory processing affecting multiple organs outside the bladder.
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DOI：
10.1042/cs20110200
发表时间：
2012-02
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Okamoto LE;Raj SR;Peltier A;Gamboa A;Shibao C;Diedrich A;Black BK;Robertson D;Biaggioni I
通讯作者：
Biaggioni I
影响因子：
2.5
作者：
Bharat, R;Kavia, C;Fowler, CJ
通讯作者：
Fowler, CJ
影响因子：
6.6
作者：
Nickel, J. Curtis;Tripp, Dean A.;Nordling, Jorgen
通讯作者：
Nordling, Jorgen
影响因子：
6.6
作者：
Clemens, JQ;Meenan, RT;Calhoun, EA
通讯作者：
Calhoun, EA
影响因子：
4.7
作者：
Reyes del Paso, Gustavo A.;Garrido, Sergio;Duschek, Stefan
通讯作者：
Duschek, Stefan