Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study.
Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study.
复制标题
DOI：
10.3389/fcvm.2021.811670
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Liu C;Liu L;Wang Y;Chen X;Liu J;Peng S;Pi J;Zhang Q;Tomlinson B;Chan P;Zhang L;Fan H;Zheng L;Liu Z;Zhang Y
高同型半胱氨酸血症（HHcy）和腹部肥胖是代谢综合征（MetS）和心血管疾病（CVD）死亡的危险因素。最近的研究表明HHcy和腹部肥胖之间存在相关性，表明它们可能对MetS和CVD死亡率的风险具有联合作用。然而，这一怀疑仍有待证实，特别是在老年人口中。我们探讨了它们对中国65岁及以上社区人群MetS和CVD死亡风险的综合影响。这项前瞻性研究于2013年5月招募了3，675名65岁及以上的中国社区居民，对全因和CVD死亡率进行了7年随访。HHcy定义为血同型半胱氨酸（Hcy）水平>15 μmol/L，腹型肥胖定义为男性腰围（WC）≥90 cm，女性腰围（HWC）≥80 cm。所有受试者根据WC和血Hcy水平分为四类：NWC（正常WC）/HHcy（-）、NWC/HHcy（+）、HWC/HHcy（-）和HWC/HHcy（+）。Logistic回归分析HHcy和腹型肥胖与MetS和代谢谱的关系，考克斯回归分析HHcy和腹型肥胖与CVD和全因死亡率的关系。中国社区老年居民中HHcy、腹型肥胖和代谢综合征的患病率分别为40.1%、59.3%和41.4%。以无HHcy和腹型肥胖[NWC/HHcy（-）]组为参照，其他3组受试者MetS及其组分异常的风险均显著增高，其中HWC/HHcy（+）组风险最高（OR = 13.52，95%CI = 8.61-14.55）。中位随访时间为6.94（±1.48）年，454例死亡，135例CVD死亡。与NWC/HHcy（-）组相比，HWC/HHcy（+）组的7年随访CVD死亡风险（HR = 1.75，95%CI = 1.02-3.03）和全因死亡风险（HR = 1.23，95%CI = 1.04-2.18）在调整主要MetS和CVD危险因素后显著增加。中国社区老年人群中高同型半胱氨酸、腹型肥胖和代谢综合征的患病率较高。高同型半胱氨酸增加代谢综合征、心血管疾病和全因死亡率的风险，尤其是在腹部肥胖人群中。
Hyperhomocysteinemia (HHcy) and abdominal obesity are risk factors for metabolic syndrome (MetS) and death from cardiovascular disease (CVD). Recent studies have shown a correlation between HHcy and abdominal obesity, suggesting that they may have a combined effect on the risk of MetS and CVD mortality. However, this suspicion remains to be confirmed, particularly in the elderly population. We explored their combined effects on the risk of MetS and CVD mortality among the community population aged 65 and above in China. This prospective study enrolled 3,675 Chinese community residents aged 65 and above in May 2013 with 7-year follow-up of all-cause and CVD mortality. HHcy was defined as the blood homocysteine (Hcy) level >15 μmol/L and abdominal obesity as waist circumference (WC) ≥90 cm for men and ≥80 cm for women (HWC). All participants were grouped into four categories by WC and the blood level of Hcy: NWC (normal WC) /HHcy(–), NWC/HHcy(+), HWC/HHcy(–), and HWC/HHcy(+). The relationship of combined HHcy and abdominal obesity with MetS and metabolic profile was evaluated by logistic regression analysis and the association of combined HHcy and abdominal obesity with CVD and all-cause mortality evaluated by Cox regression analysis. The prevalence of HHcy, abdominal obesity and MetS in elderly Chinese community residents was 40.1, 59.3, and 41.4%, respectively. Using group without HHcy and abdominal obesity [NWC/HHcy(–)] as reference, the participants of other three groups had significantly higher risk of MetS and its component abnormalities, with HWC/HHcy(+) group having the highest risk (OR = 13.52; 95% CI = 8.61–14.55). After a median of 6.94 (±1.48) years follow-up, 454 deaths occurred with 135 CVD deaths. Compared with NWC/HHcy(–) group, the risk of 7-year follow-up CVD mortality (HR = 1.75; 95% CI = 1.02–3.03) and all-cause mortality (HR = 1.23; 95% CI = 1.04–2.18) of HWC/HHcy(+) group increased considerably after adjustment for major MetS and CVD risk factors. There is high prevalence of HHcy, abdominal obesity, and MetS in the elderly Chinese community population. HHcy increases risk of MetS, CVD, and all-cause mortality, especially in the populations with abdominal obesity.
登录
查看更多内容
影响因子：
24
作者：
Levantesi, G;Macchia, A;Marchioli, R
通讯作者：
Marchioli, R
影响因子：
4.6
作者：
Fan H;Li X;Zheng L;Chen X;Lan Q;Wu H;Ding X;Qian D;Shen Y;Yu Z;Fan L;Chen M;Tomlinson B;Chan P;Zhang Y;Liu Z
通讯作者：
Liu Z
影响因子：
37.8
作者：
Abraham TM;Pedley A;Massaro JM;Hoffmann U;Fox CS
通讯作者：
Fox CS
叶酸治疗对中国成人高血压患者脑卒中一级预防的疗效 CSPPT 随机临床试验
影响因子：
120.7
作者：
Huo, Yong;Li, Jianping;Hou, Fan Fan
通讯作者：
Hou, Fan Fan
影响因子：
5.8
作者：
Lewis SJ;Lawlor DA;Nordestgaard BG;Tybjaerg-Hansen A;Ebrahim S;Zacho J;Ness A;Leary S;Smith GD
通讯作者：
Smith GD