Neuropsychological Correlates of Transcription Factor AP-2Beta, and Its Interaction with COMT and MAOA in Healthy Females
Neuropsychological Correlates of Transcription Factor AP-2Beta, and Its Interaction with COMT and MAOA in Healthy Females
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健康女性转录因子 AP-2Beta 的神经心理学相关性及其与 COMT 和 MAOA 的相互作用
DOI：
10.1159/000350997
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发表时间：
2012
影响因子：
3.2
通讯作者：
Vernaleken
中科院分区：
文献类型：
--
作者：
Schabram;Eggermann;Siegel;Gründer;Zerres;Vernaleken
背景：转录因子AP-2β已被证明影响临床和神经心理学特性。显然，它调节了编码分子的基因的转录，这些分子是儿茶酚胺能传递系统的一部分。本研究的重点是转录因子AP-2β内含子2多态性对认知表现参数的可能影响。方法：本研究以假设为导向，研究了转录因子AP-2β内含子2多态性、Val158Met儿茶酚- o -甲基转移酶（COMT）多态性和单胺氧化酶A （MAOA）可变数串联重复多态性对200名健康女性（年龄：平均±SD， 23.93±3.33岁）认知表现参数的影响及其相互作用。结果：AP-2β多态性显著影响认知表现（尤其是Trail Making Test B部分），而MAOA和COMT多态性则无显著影响。AP-2β × MAOA × COMT基因型对连续表现任务中退化刺激版本的决策偏差β有交互作用。只有Val158Met COMT多态性对人格问卷（开放性与自我超越、NEO五因素量表、气质与性格量表）有影响。结论：转录因子AP-2β内含子2多态性比MAOA和COMT多态性对认知的影响更大。AP-2β基因型可能通过调节MAOA和COMT转录以外的途径影响认知。转录因子AP-2β、COMT和MAOA多态性的相互作用表明，在多巴胺可利用性高的受试者中，转录因子AP-2β的杠杆效应更高。
Background:The transcription factor AP-2β has been shown to impact clinical and neuropsychological properties. Apparently, it regulates the transcription of genes that code for molecules which are part of the catecholaminergic transmission system. This investigation focuses on possible effects of the transcription factor AP-2β intron 2 polymorphism on cognitive performance parameters.Methods:This hypothesis-driven investigation examined the effects and interactions of the transcription factor AP-2β intron 2 polymorphism, the Val158Met catechol-O-methyltransferase (COMT) polymorphism, and the variable number of tandem repeat polymorphism of monoamine oxidase A (MAOA) on cognitive performance parameters within a group of 200 healthy women (age: mean ± SD, 23.93 ± 3.33 years).Results:The AP-2β polymorphism significantly influenced cognitive performance (in particular, the Trail Making Test part B), whereas the MAOA and COMT polymorphisms did not. However, there was an interaction effect of the AP-2β × MAOA × COMT genotypes on the decision bias β of the degraded-stimulus version of the continuous performance task. Only the Val158Met COMT polymorphism showed an influence on personality questionnaires (openness and self-transcendence; NEO Five-Factor Inventory, Temperament and Character Inventory).Conclusion:The transcription factor AP-2β intron 2 polymorphism had more influence on cognition than the MAOA and COMT polymorphisms. Possibly, the AP-2β genotype might influence cognition through pathways other than those that regulate MAOA and COMT transcription. Interactions of transcription factor AP-2β, COMT, and MAOA polymorphisms suggest higher leverage effects of transcription factor AP-2β in subjects with high dopamine availability.
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影响因子：
3.3
作者：
M. Damberg;C. Berggård;L. Farde;G. Sedvall;E. Jönsson
通讯作者：
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影响因子：
4.3
作者：
Maik C. Stuettgen;J. Hennig;M. Reuter;P. Netter
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P. Netter
DOI：
10.1017/s1461145712000764
发表时间：
2013-05-01
影响因子：
4.8
作者：
Vernaleken, Ingo;Klomp, Majken;Gruender, Gerhard
通讯作者：
Gruender, Gerhard
影响因子：
3.3
作者：
Deyoung CG;Cicchetti D;Rogosch FA;Gray JR;Eastman M;Grigorenko EL
通讯作者：
Grigorenko EL
影响因子：
10.6
作者：
Farrell, Sarah M.;Tunbridge, Elizabeth M.;Braeutigam, Sven;Harrison, Paul J.
通讯作者：
Harrison, Paul J.