Resistance Correlations Influence Infection by Foreign Pathogens.
Resistance Correlations Influence Infection by Foreign Pathogens.
复制标题
DOI：
10.1086/715013
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Hood ME
中科院分区：
文献类型：
--
作者：
Lerner N;Luizzi V;Antonovics J;Bruns E;Hood ME
相互选择促进了宿主-病原体关联的特异性和对疾病的抗性多态性。然而，植物和动物对以前在自然界中没有遇到的病原体物种的反应也各不相同，对新疾病的出现有潜在的影响。利用花药黑穗病，我们表明，抗性（衡量感染率）外来病原体可以与常设的地方性病原体的抗性变化。在蝇子草中，对地方性药黑穗病病原菌的抗性遗传变异与对另一寄主的药黑穗病病原菌的抗性变异呈正相关，但药黑穗病与坏死型病原菌之间的关系为负相关。我们提出的模型描述的遗传基础评估地方病和外来病原体之间的耐药性关系，并量化外来病原体引入后的感染概率。我们表明，即使当外来病原体具有较低的平均感染能力比地方病病原体，感染的结果是由外来病原体的感染率的宿主的遗传变异的回归的迹象和强度的变化，由地方病病原体的感染率，并通过抗性等位基因频率。鉴于入侵前的抗性平衡是由包括抗性成本在内的因素决定的，我们表明，由正相关抗性提供的对外来病原体的保护可以减少，甚至导致在人口水平上的感染风险升高，这取决于当地的动态。因此，病原体的出现潜力不仅会受到其平均感染率的影响，而且还会受到地方病所造成的优先选择所导致的抗性变异的影响。
Reciprocal selection promotes the specificity of host-pathogen associations and resistance polymorphisms in response to disease. However, plants and animals also vary in response to pathogen species not previously encountered in nature, with potential effects on new disease emergence. Using anther-smut disease, we show that resistance (measured as infection rates) to foreign pathogens can be correlated with standing variation in resistance to an endemic pathogen. In Silene vulgaris, genetic variation in resistance to its endemic anther-smut pathogen correlated positively with resistance variation to an anther-smut pathogen from another host, but the relationship was negative between anther-smut and a necrotrophic pathogen. We present models describing the genetic basis for assessing resistance relationships between endemic and foreign pathogens and for quantifying infection probabilities upon foreign pathogen introduction. We show that even when the foreign pathogen has a lower average infection ability than the endemic pathogen, infection outcomes are determined by the sign and strength of the regression of the host’s genetic variation in infection rates by a foreign pathogen on variation in infection rates by an endemic pathogen, and by resistance allele frequencies. Given that pre-invasion equilibria of resistance are determined by factors including resistance costs, we show that protection against foreign pathogens afforded by positively correlated resistances can be lessened or even result in elevated infection risk at the population level, depending on local dynamics. Therefore, a pathogen’s emergence potential could be influenced, not just by its average infection rate, but by resistance variation resulting from prior selection imposed by endemic diseases.
登录
查看更多内容
对锈病病原体的非主机抵抗 - 连续性的延续。
影响因子：
5.6
作者：
Bettgenhaeuser J;Gilbert B;Ayliffe M;Moscou MJ
通讯作者：
Moscou MJ
影响因子：
3.7
作者：
Best, SM;Kerr, PJ
通讯作者：
Kerr, PJ
DOI：
10.1098/rspb.2008.0284
发表时间：
2008-07-22
影响因子：
4.7
作者：
Davies, T. Jonathan;Pedersen, Amy B.
通讯作者：
Pedersen, Amy B.
影响因子：
5.5
作者：
ALEXANDER, HM;ANTONOVICS, J;KELLY, AW
通讯作者：
KELLY, AW
影响因子：
2.9
作者：
Antonovics, J;Hood, M;Partain, J
通讯作者：
Partain, J