The effects of the ketogenic diet on behavior and cognition.
The effects of the ketogenic diet on behavior and cognition.
复制标题
DOI：
10.1016/j.eplepsyres.2011.04.017
复制
发表时间：
2012-07
影响因子：
2.2
通讯作者：
Martin B
中科院分区：
文献类型：
--
作者：
Hallböök T;Ji S;Maudsley S;Martin B
多种形式的生酮饮食（KD）已成功用于治疗耐药癫痫，但其作为一线治疗的主流应用仍然有限。对其临床疗效以及活性分子基础的进一步研究可能有助于逆转对其实施的任何抵抗。在这篇综述中，我们将试图阐明关于KD在人类和动物中的神经保护和认知作用的实验和临床数据的现状。一般来说，许多研究小组已经表明，有效实施KD在社会行为和认知方面具有很强的神经保护作用。我们还将阐明KD在睡眠、癫痫和记忆之间有趣的关系中的作用。目前可获得的证据还表明，在适当的控制下，随着对任何潜在长期副作用的进一步研究，KD也是一种相对安全的干预措施，特别是与传统的抗癫痫药物治疗相比。此外，由于其神经保护能力，KD也可能对其他神经或神经退行性疾病的治疗有潜在的益处。
Multiple forms of the ketogenic diet (KD) have been successfully used to treat drug-resistant epilepsy, however its mainstream use as a first-line therapy is still limited. Further investigation into its clinical efficacy as well as the molecular basis of activity is likely to assist in the reversal of any resistance to its implementation. In this review we shall attempt to elucidate the current state of experimental and clinical data concerning the neuroprotective and cognitive effects of the KD in both humans and animals. Generally, it has been shown by many research groups that effective implementation of KD exerts strong neuroprotective effects with respect to social behavior and cognition. We will also elucidate the role of KD in the interesting relationship between sleep, epilepsy and memory. Currently available evidence also indicates that, under appropriate control, and with further studies investigating any potential long-term side effects, the KD is also a relatively safe intervention, especially when compared to traditional anti-epileptic pharmacotherapeutics. In addition, due to its neuroprotective capacity, the KD may also hold potential benefit for the treatment of other neurological or neurodegenerative disorders.
登录
查看更多内容
影响因子：
5.6
作者：
Bazil, CW;Walczak, TS
通讯作者：
Walczak, TS
影响因子：
4.8
作者：
Martin, Bronwen;Pearson, Michele;Mattson, Mark P.
通讯作者：
Mattson, Mark P.
影响因子：
--
作者：
Maalouf M;Rho JM;Mattson MP
通讯作者：
Mattson MP
影响因子：
2.6
作者：
Bazil, CW
通讯作者：
Bazil, CW
影响因子：
2.6
作者：
Becker, DA;Fennell, EB;Carney, PR
通讯作者：
Carney, PR