Quantitative proteome and phosphoproteome datasets of DNA replication and mitosis in Saccharomyces cerevisiae.
Quantitative proteome and phosphoproteome datasets of DNA replication and mitosis in Saccharomyces cerevisiae.
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DOI：
10.1016/j.dib.2022.108741
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发表时间：
2022-12
期刊：
影响因子：
1.2
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞分裂是一个高度调节的过程，确保从酵母到人类的所有生物体都能产生健康的后代。这一过程的失调可导致不受控制的细胞增殖和基因组不稳定性，这两者都是癌症的标志。细胞周期进程由激酶和磷酸酶的复杂网络决定。这些酶以高度特异性的时间方式作用于其底物，确保细胞分裂过程是单向和不可逆的。细胞周期的关键事件，如遗传物质的复制及其向子细胞的再分配，分别发生在S期和有丝分裂中。在这些细胞周期阶段，破译磷酸化/去磷酸化事件的动力学是重要的。在这里，我们展示了一个定量蛋白质组学和磷酸化蛋白质组学质谱数据集，该数据集描述了模型生物S中S期和有丝分裂停滞期间发生的早期和晚期磷酸化事件以及相关蛋白质组改变。啤酒。该数据集具有广泛的意义，因为控制细胞周期进程的分子机制在整个进化过程中是保守的。该数据已存入ProteomeXchange，数据集标识符为PXD 037291。
Cell division is a highly regulated process that secures the generation of healthy progeny in all organisms, from yeast to human. Dysregulation of this process can lead to uncontrolled cell proliferation and genomic instability, both which are hallmarks of cancer. Cell cycle progression is dictated by a complex network of kinases and phosphatases. These enzymes act on their substrates in a highly specific temporal manner ensuring that the process of cell division is unidirectional and irreversible. Key events of the cell cycle, such as duplication of genetic material and its redistribution to daughter cells, occur in S-phase and mitosis, respectively. Deciphering the dynamics of phosphorylation/dephosphorylation events during these cell cycle phases is important. Here, we showcase a quantitative proteomic and phosphoproteomic mass spectrometry dataset that profiles both early and late phosphorylation events and associated proteome alterations that occur during S-phase and mitotic arrest in the model organism S. cerevisiae. This dataset is of broad interest as the molecular mechanisms governing cell cycle progression are conserved throughout evolution. The data has been deposited in ProteomeXchange with the dataset identifier PXD037291.
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3.3
作者：
Paulo, Joao A.;O'Connell, Jeremy D.;Gygi, Steven P.
通讯作者：
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DOI：
10.1007/s13361-018-1946-6
发表时间：
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影响因子：
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7.4
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4.4
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