Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange.
Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange.
复制标题
DOI：
10.1016/j.biomaterials.2018.03.060
复制
发表时间：
2018-09
期刊：
影响因子：
14
通讯作者：
Anseth KS
中科院分区：
文献类型：
--
作者：
Brown TE;Carberry BJ;Worrell BT;Dudaryeva OY;McBride MK;Bowman CN;Anseth KS
The extracellular matrix (ECM) constitutes a viscoelastic environment for cells. A growing body of evidence suggests that the behavior of cells cultured in naturally-derived or synthetic ECM mimics is influenced by the viscoelastic properties of these substrates. Adaptable crosslinking strategies provide a means to capture the viscoelasticity found in native soft tissues. In this work, we present a covalent adaptable hydrogel based on thioester exchange as a biomaterial for the in vitro culture of human mesenchymal stem cells. Through control of pH, gel stoichiometry, and crosslinker structure, viscoelastic properties in these crosslinked networks can be modulated across several orders of magnitude. We also propose a strategy to alter these properties in existing networks by the photo-uncaging of the catalyst 4-mercaptophenylacetic acid. Mesenchymal stem cells encapsulated in thioester hydrogels are able to elongate in 3D and display increased proliferation relative to those in static networks.
登录
查看更多内容
DOI：
10.1002/adma.201303680
发表时间：
2014-02-12
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
McKinnon DD;Domaille DW;Cha JN;Anseth KS
通讯作者：
Anseth KS
影响因子：
16.6
作者：
Chaudhuri O;Gu L;Darnell M;Klumpers D;Bencherif SA;Weaver JC;Huebsch N;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
5.5
作者：
David, R. L. Ameri;Kornfield, Julia A.
通讯作者：
Kornfield, Julia A.
影响因子：
41.2
作者：
Chaudhuri O;Gu L;Klumpers D;Darnell M;Bencherif SA;Weaver JC;Huebsch N;Lee HP;Lippens E;Duda GN;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
46.2
作者：
Brown TE;Anseth KS
通讯作者：
Anseth KS